Results 121 to 130 of about 588,441 (286)

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

open access: yesPhytotherapy Research, EarlyView.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam   +7 more
wiley   +1 more source

Neurological effects of fat embolism syndrome: A case report

open access: yes, 2017
Fat embolism syndrome is a serious multi-system pathology which classically affects the respiratory system, neurological system and causes a petechial rash.
Nigel Hollister   +2 more
core   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Cerebral fat embolism following cardiac surgery.

open access: yes, 1983
We describe 3 cases of cerebral fat embolism associated with cardiac surgery. The autopsy findings suggested that in 2 cases, the embolic fat globules entered the systemic circulation directly as a result of protrusion of epicardial fat into the left ...
G G deBlois, R J Sinnenberg, N R Ghatak
core   +1 more source

Impact of Positively Charged Backbone Modifications on the Properties of Spherical Nucleic Acids

open access: yesSmall, EarlyView.
A synthesis of spherical nucleic acids (SNAs) featuring cationic backbone modifications is presented, together with an analysis of their emerging properties. Introducing positively charged guanidinium groups near the SNA surface enhances cellular uptake and offers a pathway toward more precise control over SNA internalization.
Katherine E. Bujold   +4 more
wiley   +1 more source

Maternal Lead Exposure Induces Glandular Alterations in the Salivary Glands of Rat Male Offspring

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Lead (Pb) is a widely distributed environmental pollutant that is highly noxious due to its toxicokinetic characteristics. Pb exposure can damage vital organ systems, including the central nervous and stomatognathic systems. As salivary glands play an important role in oral homeostasis, this study aimed to investigate the effects of maternal ...
Rayssa Maitê Farias Nazário   +8 more
wiley   +1 more source

Fat embolism mimicking pulmonary embolism: A case report

open access: yes
Fat embolism syndrome is a rare clinical entity. The diagnosis is largely clinical, with the imaging studies supporting the clinical diagnosis. Here we present the case of a 19-year-old boy who presented with a tibial fracture and developed sudden onset ...
Chathuri Munagama   +3 more
core   +1 more source

Paradoxical Cerebral Fat Embolism in an Adolescent PLHA: A Convergence of Trauma, ART Induced Hypercoagulability, and Septal Heart Defect

open access: yesCase Reports in Clinical Practice
Fat embolism syndrome (FES) is a life-threatening complication following long bone fractures, primarily affecting the pulmonary circulation. However, cerebral fat embolism (CFE) is a rare yet severe variant that can occur when fat emboli bypass the ...
Abhijeet Sharma, Akansha Jain
doaj   +1 more source

immunoHuMiX: A personalizable gut‐on‐chip model for unraveling human microbiome–immune interactions

open access: yesVIEW, EarlyView.
The study introduces a personalized gut model that brings together human immune cells and intestinal cells to better mimic how the body interacts with microbes. This system successfully maintained both human cells and a 17‐strain probiotic community, showing consistent immune responses across different donors.
Charlotte De Rudder   +26 more
wiley   +1 more source

On diagnosis of fat embolism in the putrefactive lungs

open access: yes, 2020
The results of biochemical analysis of rabbit lungs in case of death due to fat embolism and mechanical asphyxia (control) are presented. Reliable difference in lipid quantities was evident both immediately after death and in different putrefaction ...
Purdyaev Yu.S., Alisievich V.I.
core  

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