Results 121 to 130 of about 14,755 (236)

Melanoma: Pathogenesis and Targeted Therapy

MedComm, Volume 7, Issue 1, January 2026.
The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Yang Fu, Jie Liu, Zeming Mo, Bin Wang, Yaotiao Deng, Yu Jiang   +5 more
wiley   +1 more source

Pulmonary micro-tumor emboli resulting in paradoxical emboli: a case report

Pulmonary Circulation, 2018
Pulmonary tumor embolism (PTE) is a rare manifestation of cancer. It is characterized by the presence of tumor cell emboli in the pulmonary arterioles and capillaries leading to an elevation of pulmonary vascular resistance.
Louis-Vincent Morin-Thibault, Daniel Wiseman, Michelle Fortin, Christian Couture, Steeve Provencher   +4 more
doaj   +1 more source

Clinical characteristics, management and outcome of major pulmonary embolism: an experience from a tertiary care center in Pakistan [PDF]

, 2009
OBJECTIVE: To evaluate the clinical characteristics, risk factors, management and outcome of major pulmonary embolism (PE) in a tertiary care center of Karachi.
Atif, Muhammad, Fatima, Kulsoom, Husain, Shahid Javed, Irfan, Muhammad, Saeed, Muhammad Ammad, Zubairi, Ali Bin Sarwar   +5 more
core   +1 more source

Transcranial Doppler Ultrasound to Find Patent Foramen Ovale Before Left Ventricular Assist Device Placement

Clinical Neuroimaging, Volume 3, Issue 1, 2026.
ABSTRACT Background and purpose Detection of patent foramen ovale (PFO) has become important with the increasing use of left ventricular assist devices (LVAD) for advanced heart failure. After LVAD implantation there may be increased right to left shunting through a PFO causing hypoxemia.
Ryan Tudino, Sanjay Anandaram, Patricia Oates, Nabil Matmati, Scott Feitell, Kelly Matmati   +5 more
wiley   +1 more source

Integrated In Silico and In Vitro Study of Copper Nanocatalyzed Carbonyl‐Functionalized Triazoles—Inducing S Phase Cell Cycle Arrest and Apoptosis in MCF‐7

ChemistryOpen, Volume 15, Issue 1, January 2026.
A targeted drug discovery pipeline identified novel copper‐nanocatalyzed carbonyl‐functionalized triazoles as potent breast cancer therapeutics (selectivity index up to 4.44). Lead compounds (3i, 3j) induced apoptosis in breast cancer cells (MCF‐7) by modulating BAX/BCL2, causing reactive oxygen species (ROS)‐mediated glutathione (GSH) depletion ...
Joydip Mondal, Tiasha Dasgupta, Chitluri Kiran Kumar, Prasanth Babu Nandagopal, Sadananda Mal, Sourav Paul, Aishwarya S, Chayan Pandya, Isaac Arnold Emerson, Venkatraman Manickam, Akella Sivaramakrishna   +10 more
wiley   +1 more source

Acute pulmonary embolectomy [PDF]

, 2017
Acute pulmonary embolism (PE) is a common condition frequently associated with a high mortality worldwide. It can be classified into non-massive, sub-massive and massive, based on the degree of haemodynamic compromise.
Choong, Cliff K.C., He, Cheng, Kappetein, Pieter A., Mestres, Carlos A., Smith, Julian A., Von Segesser, Ludwig K.   +5 more
core  

Genotype Differences and Hydroxyurea Utilization Among Adults With Moderate to Severe Sickle Cell Disease

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 1, January 2026.
ABSTRACT Backgrounds Hydroxyurea (HU) remains underutilized in adults with sickle cell disease (SCD) despite proven benefits. Current HU guidelines primarily target sickle cell anemia (SCA), overlooking other genotypes. Objectives This study examined HU utilization patterns across genotypes among adults considered to have moderate to severe SCD ...
Siang‐Hao Cheng, Enrico M. Novelli, Hyeun Ah Kang, Terri V. Newman, Kangho Suh   +4 more
wiley   +1 more source

Knowledge Gaps and Controversies on Cardiopulmonary Exercise Testing in the Assessment of Pulmonary Vascular Disease: An Official Statement of the Pulmonary Vascular Research Institute Exercise and Right Ventricular Function Task Force

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT Exercise testing has long been essential for evaluating diagnosis, prognosis, and functional status in pulmonary hypertension (PH). Recent advances have clarified its role in defining reference values and prognostic markers. Nonetheless, substantial knowledge gaps persist regarding the implementation of invasive cardiopulmonary exercise ...
Aaron B. Waxman, Abraham Babu, Roberto Badagliacca, Eloara Ferreira, Patty George, Marco Guazzi, Luke Howard, Darlene Kim, Gabor Kovacs, Saad Kubba, David Langleben, Colm McCabe, Thais Menezes, Rudolf Oliveira, Stylianos Orfanos, Inderjit Singh, David Systrom, Ryan Tedford, Rebecca Vanderpool, Carmine Dario Vizza, Franz P. Rischard   +20 more
wiley   +1 more source

Acquired whole-lung mismatched perfusion defects on pulmonary ventilation/perfusion scintigraphy [PDF]

, 2018
Alberg, Holmes, Pickhardt, Raghu, Rossi, Saad, Slonim, Sostman   +7 more
core   +2 more sources

Use of biomarkers or echocardiography in pulmonary embolism: the Swiss Venous Thromboembolism Registry [PDF]

, 2017
Background: Cardiac biomarkers and echocardiography for assessing right ventricular function are recommended to risk stratify patients with acute non-massive pulmonary embolism (PE), but it remains unclear if these tests are performed systematically in ...
Amann-Vesti, B., Aujesky, D., Baldi, T., Baumgartner, I., Brugger, A., Hayoz, D., Husmann, M., Kucher, N., Spirk, D., Willenberg, T.   +9 more
core