Results 71 to 80 of about 547,146 (311)

Specification of cell fate in the sea urchin embryo: summary and some proposed mechanisms [PDF]

, 1998
An early set of blastomere specifications occurs during cleavage in the sea urchin embryo, the result of both conditional and autonomous processes, as proposed in the model for this embryo set forth in 1989.
Cameron, R. Andrew, Davidson, Eric H., Ransick, Andrew   +2 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Biotransformation of zearalenone to non-estrogenic compounds with two novel recombinant lactonases from Gliocladium

BMC Microbiology
Background The mycotoxin zearalenone (ZEA) produced by toxigenic fungi is widely present in cereals and its downstream products. The danger of ZEA linked to various human health issues has attracted increasing attention.
Zongping Sun, Yuting Fang, Yaohuan Zhu, Wen Tian, Junjie Yu, Jun Tang   +5 more
doaj   +1 more source

Associations Between Asthma and Polycystic Ovary Syndrome: Current Perspectives

Frontiers in Endocrinology, 2022
A potential correlation between polycystic ovary syndrome (PCOS) and asthma, used to be identified as diseases originating from two independent systems, has been supported by increasing evidence. From an epidemiological perspective, mounting studies have
Yue Xu, Zhi-Yang Zhou, Jie-Xue Pan, He-Feng Huang, He-Feng Huang, He-Feng Huang   +5 more
doaj   +1 more source

Potential role of p53 protein as a novelbiomarker of sperm quality, able to predict thesuccess of ART techniques. EcoFoodFertility Project [PDF]

, 2018
Introduction: Protein p53 is well known as “The guardian of genome”; it changes its concentration in human spermatozoa DNAin relation to the damage of the latter.
Liana Bosco, Luigi Montano, Maria Cira Gentile, Salvatore Raimondo, Tiziana Tiziana Notari, Tommaso Gentile   +5 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice

Frontiers in Pharmacology
ObjectiveHepatic ischemia-reperfusion injury (HIRI) frequently occurs as a complication in liver surgeries, which significantly impacting patient outcomes.
Yihong Yang, Guanghua Xiong, Huangqi Shi, Yulin Peng, Jinghong Liu, Yaxuan Jiang, Min Lu, Hongbo Liu, Yong Liu   +8 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Genotypic variation of dormancy in wheat (Triticum aestivum L.) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science, Department of Plant Science, Massey University, Palmerston North, New Zealand [PDF]

, 1996
Embryo dormancy and α - amylase dormancy are desirable in wheat to minimise pre-harvest sprouting damage. The current work focuses on the embryo and graincoat colour.
Zvomuya, Norman
core  

Monoamine oxidase A expression is vital for embryonic brain development by modulating developmental apoptosis [PDF]

, 2011
Monoamine oxidases (MAO-A, MAO-B) metabolize biogenic amines and have been implicated in neuronal apoptosis. Although apoptosis is an important process in embryo development, the role of MAO isoenzymes has not been investigated in detail.
Alwan, Bach, Beglopoulos, Billett, Bortner, Borue, Burnet, Cases, Cecconi, Chen, Chen, Chen, Chen, Cheng, Chiou, Cohen, Cole, Copp, Fitzgerald, Geha, Grimsby, Guo, Imai, Jahng, Kuida, Luo, Mateyak, McClellan, Naoi, Ou, Popova, Santoni-Rugiu, Scott, Scrutton, Senechal, Shih, Stankovski, Suarez-Merino, Syagailo, Ufer, Ufer, Upton, Van Maele-Fabry, Vitalis, Wang, Youdim   +45 more
core   +1 more source