Results 321 to 330 of about 1,437,405 (386)

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation. [PDF]

Cell Death Differ
Deng N, Li G, Zhang L, Wang P, Liu M, He B, Tang Y, Cai H, Lu J, Wang H, Deng W, Bao H, Kong S.   +12 more
europepmc   +1 more source

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

Twinning and Recombination: A Review of the Data [PDF]

, 1981
Filice, Francis P.
core   +1 more source

Intralitter Variability Influences the Developmental Impact of Valproic Acid Exposure in CD‐1 Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Valproic acid (VPA) is an antiepileptic and mood‐stabilizing drug that causes teratogenic effects, including neural tube defects (NTDs), when taken during pregnancy. Although animal models are widely used to study VPA teratogenicity, most rely on litter means, which overlook variability within the litter.
Lauren T. L. Brown, Megan E. Cull, Lihua Xue, Louise M. Winn   +3 more
wiley   +1 more source

Fertility and Early Embryonic Development Toxicity of hzVSF‐v13 in Sprague–Dawley Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT Humanized virus suppressing factor–variant 13 (hzVSF‐v13), a monoclonal IgG4 antibody, is a potential therapeutic candidate for COVID‐19. Although fertility and embryonic developmental toxicity studies are crucial for the safety evaluation of new drugs, the toxicological profile of hzVSF‐v13 remains unexplored.
Ji‐Seong Jeong, Sang‐Yun Kim, Jinsoo Lee, Seung‐Jin Lee, Onju Ham, Woojin Kim, Wan‐Jung Im, Sungman Park, Kyong‐Cheol Ko, Jong‐Choon Kim, Yong‐Bum Kim   +10 more
wiley   +1 more source

Differential expression of tsRNAs and miRNAs in embryo culture medium: potential impact on embryo implantation. [PDF]

J Assist Reprod Genet
Xiong Y, Shi L, Zhang M, Zhou C, Mao Y, Hong Z, Wang Z, Ma L.   +7 more
europepmc   +1 more source

Rehabilitating Bioethics: Recontextualizing In Vitro Fertilization outside Contractual Autonomy [PDF]

, 2004
Lin, Olivia
core   +1 more source

A successful in vitro fertilization outcome in a hermaphrodite male

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 424-425, April 2025.
Shima Elbakhit M. E. Albasha, Sami Saadi Al‐Said, Haitham Tharwat M. H. El Bardisi   +2 more
wiley   +1 more source

Frozen Pre-Embryos and the Right To Change One’s Mind [PDF]

, 2002
Shapo, Helene S.
core   +1 more source