Results 151 to 160 of about 1,397,312 (365)

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

Case of ST-Elevation Myocardial Infarction in a 32-Year-Old Male Receiving Bleomycin, Etoposide, and Cisplatin Chemotherapy for Embryonal Carcinoma. [PDF]

Cureus, 2023
Bassil E, Singh H, Ahmed O, Parikh S.
europepmc   +1 more source

Embryonal carcinoma of the ovary.A clinicopathologic entity distinct from endodermal sinus tumor resembling embryonal carcinoma of the adult testis [PDF]

, 1976
Robert J. Kurman, Henry J. Norris
openalex   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Metastatic Testicular Embryonal Carcinoma Presenting as Gastrointestinal Hemorrhage. [PDF]

ACG Case Rep J, 2021
Park N, Han J, Shah S, Chahine A, Samarasena J.   +4 more
europepmc   +1 more source

Embryonal carcinoma of the ovary [PDF]

Cancer, 1962
R D, NEUBECKER, J L, BREEN
openaire   +2 more sources

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features

Cancer Medicine, 2019
Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really represent extragondal primary
Andrea Ronchi, Immacolata Cozzolino, Marco Montella, Iacopo Panarese, Federica Zito Marino, Sabrina Rossetti, Paolo Chieffi, Marina Accardo, Gaetano Facchini, Renato Franco   +9 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Multilocular Cystic Nephroma – A Surgical and Radiological Dilemma [PDF]

, 2011
Multilocular cystic nephroma is a slow growing benign renal tumor. It has been identified as exclusive adult lesion, more common in females. It commonly occurs as an asymtomatic mass, occasionally with hematuria.
Anil Malleshi Betigeri , Boopathi subramaniyam, Int J Cur Bio Med Sci.
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