Results 181 to 190 of about 1,397,312 (365)

LRWD1 expression is regulated through DNA methylation in human testicular embryonal carcinoma cells. [PDF]

open access: yesBasic Clin Androl, 2021
Hung JH   +8 more
europepmc   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo   +6 more
wiley   +1 more source

Differential Incorporation of β-actin as A Component of RNA Polymerase II into Regulatory Regions of Stemness/Differentiation Genes in Retinoic Acid-Induced Differentiated Human Embryonic Carcinoma Cells

open access: yesCell Journal, 2016
Objective Nuclear actin is involved in transcription regulation by recruitment of histone modifiers and chromatin remodelers to the regulatory regions of active genes.
Khadijeh Falahzadeh   +2 more
doaj  

Mapping CSC‐Mediated Ovarian Cancer Chemoresistance via CXCR4‐PET to Guide Precision Cisplatin Re‐Sensitization Therapy

open access: yesAdvanced Science, EarlyView.
CXCR4 functions as a potential cancer stem cell‐associated marker linked to chemoresistance in ovarian cancer, and an inhibitor of CXCR4, AMD3100, can enhance the cytotoxic response to cisplatin. Based on these findings, [68Ga]Ga‐Pentixafor positron emission tomography enables selective visualization of CXCR4‐high ovarian cancer, while AMD3100 combined
Lixia Feng   +12 more
wiley   +1 more source

Expression and function of FGF-4 in peri-implantation development in mouse embryos [PDF]

open access: yes, 1994
One of the earliest events in mammalian embryogenesis is the formation of the inner cell mass (ICM) and the subse- quent delamination of primitive endoderm.
Basilico, Claudio   +3 more
core   +1 more source

Data from Differentiation of Human Embryonal Carcinomas <i>In vitro</i> and <i>In vivo</i> Reveals Expression Profiles Relevant to Normal Development

open access: gold, 2023
Rolf I. Skotheim   +10 more
openalex   +1 more source

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