Results 71 to 80 of about 1,394,800 (224)

Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts [PDF]

, 2011
The transcription factor Ets-1 is known to be involved in a broad variety of cellular functions such as cell proliferation, migration, invasion, apoptosis and angiogenesis.
Edwards, Dyaln R., Florin, Alexandra, Fuchs, Tanja, Hahne, Jens Claus, Pourtier, Albin, Soncin, Fabrice, Wernert, Nicolas   +6 more
core   +1 more source

Dysgerminoma with Embryonal Carcinoma, a Rare Ovarian Malignant Mixed Germ Cell Tumor in a 13-Year-Old Girl: A Case Report [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān
Introduction: Pediatric patients rarely develop ovarian tumors, but mainly develop ovarian germ cell tumors. Malignant germ cell tumors are generally rare and dysgerminoma is the most frequent malignant ovarian neoplasm in young and adolescent girls.
Mahsa Akbari Oryani, Farzaneh Akbari, Marjaneh Farazestanian, Sare Etemad   +3 more
doaj   +1 more source

The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas

Molecular Oncology, 2022
Testicular germ cell tumors (GCTs) are stratified into seminomas and nonseminomas. Seminomas share many histological and molecular features with primordial germ cells, whereas the nonseminoma stem cell population—embryonal carcinoma (EC)—is pluripotent ...
Margaretha A. Skowron, Teresa K. Becker, Lukas Kurz, Sina Jostes, Felix Bremmer, Florian Fronhoffs, Kai Funke, Gamal A. Wakileh, Melanie R. Müller, Aaron Burmeister, Thomas Lenz, Anja Stefanski, Kai Stühler, Patrick Petzsch, Karl Köhrer, Peter Altevogt, Peter Albers, Glen Kristiansen, Hubert Schorle, Daniel Nettersheim   +19 more
doaj   +1 more source

Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors [PDF]

, 2015
Dysregulation of the cell cycle and cyclin-dependent kinases (cdks) is a hallmark of cancer cells. Intervention with cdk function is currently evaluated as a therapeutic option in many cancer types including neuroblastoma (NB), a common solid tumor of ...
Eggert, Angelika, Koester, Johannes, Lee, Sangkyun, Morik, Katharina, Schramm, Alexander, Schulte, Johannes H, Schwermer, Melanie, Stephan, Harald, Van Maerken, Tom   +8 more
core   +2 more sources

Identification of ERβ1 and ERβ2 in human seminoma, in embryonal carcinoma and in their adjacent intratubular germ cell neoplasia

Reproductive Biology and Endocrinology, 2009
Background Estrogens exert a role on germ cell physiology of normal human testis through the mediation of the estrogen receptor (ER) beta subtypes. Epidemiological studies evidenced an increased incidence of testicular germ cell cancer after elevated pre-
Rago Vittoria, Romeo Francesco, Giordano Francesca, Ferraro Aurora, Andò Sebastiano, Carpino Amalia   +5 more
doaj   +1 more source

Oct4-Mediated Inhibition of Lsd1 Activity Promotes the Active and Primed State of Pluripotency Enhancers

Cell Reports, 2020
Summary: An aberrant increase in pluripotency gene (PpG) expression due to enhancer reactivation could induce stemness and enhance the tumorigenicity of cancer stem cells.
Lama AlAbdi, Debapriya Saha, Ming He, Mohd Saleem Dar, Sagar M. Utturkar, Putu Ayu Sudyanti, Stephen McCune, Brice H. Spears, James A. Breedlove, Nadia A. Lanman, Humaira Gowher   +10 more
doaj   +1 more source

Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma. [PDF]

, 2019
BackgroundPlexiform fibromyxoma (PF) is a rare gastric tumor often confused with gastrointestinal stromal tumor. These so-called "benign" tumors often present with upper GI bleeding and gastric outlet obstruction.
Banerjee, Sudeep, Burgoyne, Adam M, Corless, Christopher L, Davis, Jessica L, Miettinen, Markku M, Noh, Sangkyu, Sicklick, Jason K, Tang, Chih-Min, Ustoy, Rowan, Yebra, Mayra   +9 more
core   +1 more source

Production of stable GFP-expressing neural cells from P19 embryonal carcinoma stem cells [PDF]

, 2017
Murine P19 embryonal carcinoma (EC) cells are convenient to differentiate into all germ layer derivatives. One of the advantages of P19 cells is that the exogenous DNA can be easily inserted into them.
Bakhshalizadeh, Shabnam., Ebrahimie, Esmaeil., Ebrahimie, Marzieh., Esmaeili, Fariba., shirzad, Hedayatollah.   +4 more
core   +1 more source

Downregulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1

Cell Death and Disease, 2010
Our previous studies have shown that microRNA-383 (miR-383) expression is downregulated in the testes of infertile men with maturation arrest (MA). However, the underlying mechanisms of miR-383 involved in the pathogenesis of MA remain unknown.
J. Lian, H. Tian, L. Liu, X-S Zhang, W-Q Li, Y-M Deng, G. Yao, Mianmian Yin, F. Sun   +8 more
semanticscholar   +1 more source

Foxm1 transcription factor is required for maintenance of pluripotency of P19 embryonal carcinoma cells

Nucleic Acids Research, 2010
Transcription factor Foxm1 plays a critical role during embryonic development and its expression is repressed during retinoic acid (RA)-induced differentiation of pluripotent P19 embryonal carcinoma cells at the early stage, correlated with ...
Zhongqiu Xie, Guixiang Tan, M. Ding, D. Dong, Tuanhui Chen, Xiangxian Meng, Xiaoqin Huang, Yongjun Tan   +7 more
semanticscholar   +1 more source