Results 81 to 90 of about 1,397,312 (365)

Down-regulatory effects of miR-211 on long non-coding RNA SOX2OT and SOX2 genes in esophageal squamous cell carcinoma [PDF]

, 2016
Objective: MicroRNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) that transcriptionally or post-Transcriptionally regulate gene expression through degradation of their mRNA targets and/or translational suppression.
Aleyasin, S.A., Mowla, S.J., Semnani, S., Shafiee, M., Vasei, M.   +4 more
core  

Effects of selegiline, a monoamine oxidase B inhibitor, on differentiation of P19 embryonal carcinoma stem cells, into neuron-like cells [PDF]

, 2011
Selegiline, the irreversible inhibitor of monoamine oxidase B (MAO-B), is currently used to treat Parkinson's disease. However, the mechanism of action of selegiline is complex and cannot be explained solely by its MAO-B inhibitory action.
Bakhshalizadeh, Shabnam., Esmaeili, Fariba., Houshmand, Fariba., Saedi-Marghmaleki, Mojtaba., shirzad, Hedayatollah.   +4 more
core   +1 more source

Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: Confirmation of OCT3/4 specificity for germ cell tumours [PDF]

, 2011
Background: OCT3/4 (POU5F1) is an established diagnostic immunohistochemical marker for specific histological variants of human malignant germ cell tumours (GCTs), including the seminomatous types and the stem cell component of non-seminomas, known as ...
A J M Gillis, A M Hoogland, AJ Gillis, AT Collins, BR Krishnan, CJ Lengner, D Pain, DC Hay, DM Lai, G J L H van Leenders, G Jenster, G Suo, H A D M van Herk, H Niwa, H Stoop, H Zaehres, J de Jong, J de Jong, J de Jong, J de Jong, J de Jong, J Kehler, J Lee, J Martens, J Takeda, JM Velkey, JW Oosterhuis, KJ Livak, L Cheng, L H J Looijenga, L Looijenga, L Poliseno, L Ricci-Vitiani, LH Looijenga, LHJ Looijenga, M A Rijlaarsdam, M Pesce, M Pesce, M Timmermans, MH Asadi, MH Tai, MM Matin, N Xu, NJ van Casteren, P Sotomayor, PW Andrews, RA Sturm, RB Marques, S Liedtke, S Liedtke, S Zhao, SI Papamichos, SK Hussain, T Cantz, UI Ezeh, V Botquin, W Dinjens, WM van Weerden, X Wang, Y Atlasi, Y Atlasi, Y Gao, YC Chen   +62 more
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Giant Mediastinal Germ Cell Tumour: An Enigma of Surgical Consideration

Case Reports in Surgery, 2016
We present a case of 16-year-old male, who was referred from private centre for dyspnoea, fatigue, and orthopnea. The chest radiograph revealed complete opacification of left chest which was confirmed by computed tomography as a large left mediastinal ...
Firdaus Hayati, Nurayub Mohd Ali, Levin Kesu Belani, Nornazirah Azizan, Andee Dzulkarnaen Zakaria, Mohd Ramzisham Abdul Rahman   +5 more
doaj   +1 more source

Embryonal Carcinoma Of The Testis masquerading As Epididymitis [PDF]

Journal of Clinical and Biomedical Sciences, 2012
Dr.Prema Saldanha
doaj   +2 more sources

Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells

Journal of Cell Biology, 1982
Murine embryonal carcinoma cells can differentiate into a varied spectrum of cell types. We observed the abundant and precocious development of neuronlike cells when embryonal carcinoma cells of various pluripotent lines were aggregated and cultured in ...
E. Jones-Villeneuve, M. McBurney, K. Rogers, V. Kalnins   +3 more
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Germ Cell Tumor Presenting with Precocious Puberty in a Girl in United Arab Emirates

Dubai Medical Journal, 2020
We herein report a rare case of malignant mixed germ cell tumor comprising both an embryonal carcinoma (60%) and a yolk sac tumor (40%). A 7-year-old girl presented to the emergency department with persistent vaginal bleeding, abdominal pain, and ...
Asim Noor Rana, Hani Humad, Aeman Muhammad Asif, Dana Ghannam, Nadia Nadeem   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source