Results 221 to 230 of about 387,135 (307)

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Early pregnancy with low β-hCG levels progressing to severe preeclampisa: a case report highlighting individualized management strategies. [PDF]

Front Med (Lausanne)
Pang L, Fang Q, Pan X, Ruan H.
europepmc   +1 more source

Kinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐Repair

Advanced Science, EarlyView.
This study shows that kinesin‐driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self‐repair and leads to filament failure. While curvature, motor motility, and force individually cause limited damage, their combination overwhelms repair.
Shweta Nandakumar, Jonas Bosche, Mirko Wieczorek, Constantin Matteo Albrecht, Belinda König, Mona Grünewald, Ludger Santen, Stefan Diez, Reza Shaebani, Laura Schaedel   +9 more
wiley   +1 more source

Alternative splicing dynamics during human cardiac development in vivo and in vitro. [PDF]

Stem Cell Reports
Gomes-Silva B, Furtado M, Ribeiro M, Martins S, Carvalho T, Ventura-Gomes A, Maatz H, Parakkat P, Crocini C, Gotthardt M, Savisaar R, Carmo-Fonseca M.   +11 more
europepmc   +1 more source

The Woman and the Physician Facing Abortion: The Role of Correct Science in the Formation of Conscience and the Moral Decision Making Process [PDF]

, 2000
Irving, Dianne N.
core   +1 more source

BZW1 Drives Immune Evasion in Lung Adenocarcinoma via Ferroptosis Suppression

Advanced Science, EarlyView.
BZW1 attenuates ferroptosis by competitively binding NCOA4 and suppress ferrtinophagy‐mediated iron release. The depletion of BZW1 triggers lipid peroxidation through iron homeostasis. Extracellularly, BZW1 attenuates immunogenic cell death and reinvigorates cytotoxic T‐cell responses.
Linyao Zhao, Yue Peng, Qing Liang, Shi Liu, Yang Li, Lei Ma, Menghan Hu, Sujuan Zheng, Zhihua Liu, Shugeng Gao   +9 more
wiley   +1 more source

The persisting presence of absence in female sex development: a critical interdisciplinary reflection. [PDF]

Biol Sex Differ
Stammberger B, Steinbach X, Hornig N.
europepmc   +1 more source

Twinning and Recombination: A Review of the Data [PDF]

, 1981
Filice, Francis P.
core   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Prenatal cannabis smoke exposure alters placental development in a murine model of pregnancy. [PDF]

PLoS One
Podinic T, Sunil M, MacAndrew A, Monaco C, Lee G, Lockington C, Petrik J, Lucas AM, Tomy T, Tomy G, Kasinska J, Jamshed L, Holloway AC, Ratcliffe EM, Raha S.   +14 more
europepmc   +1 more source