Results 91 to 100 of about 481,310 (353)

Zebrafish embryonic explants undergo genetically encoded self-assembly

eLife, 2020
Embryonic stem cell cultures are thought to self-organize into embryoid bodies, able to undergo symmetry-breaking, germ layer specification and even morphogenesis.
Alexandra Schauer, Diana Pinheiro, Robert Hauschild, Carl-Philipp Heisenberg   +3 more
doaj   +1 more source

Specialized mouse embryonic stem cells for studying vascular development. [PDF]

, 2014
Vascular progenitor cells are desirable in a variety of therapeutic strategies; however, the lineage commitment of endothelial and smooth muscle cell from a common progenitor is not well-understood.
Burns, Andrew B, Fan, Yuhong, Glaser, Drew E, Hatano, Rachel, McCloskey, Kara E, Medrzycki, Magdalena   +5 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest

eLife
 The histone methyltransferase Polycomb repressive complex 2 (PRC2) is required for specification of the neural crest, and mis-regulation of neural crest development can cause severe congenital malformations. PRC2 is necessary for neural crest induction,
Tim Casey-Clyde, S John Liu, Angelo Pelonero, Juan Antonio Camara Serrano, Camilla Teng, Yoon-Gu Jang, Harish N Vasudevan, Arun Padmanabhan, Jeffrey Ohmann Bush, David R Raleigh   +9 more
doaj   +1 more source

Function of Bmpr1a in ES cell differentiation and cell competition [PDF]

, 2010
Bone morphogenetic protein (BMP) 4 signalling via BMPR1A is required for the maintenance of the epiblast in the early embryo, and for self-renewal of pluripotent mouse embryonic stem (ES) cells by inhibiting neural differentiation.
Sancho, Maria Margarida Gouveia, Sancho, Maria Margarida Gouveia   +1 more
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Phalaenopsis LEAFY COTYLEDON1-Induced Somatic Embryonic Structures Are Morphologically Distinct From Protocorm-Like Bodies

Frontiers in Plant Science, 2019
Somatic embryogenesis is commonly used for clonal propagation of a wide variety of plant species. Induction of protocorm-like-bodies (PLBs), which are capable of developing into individual plants, is a routine tissue culture-based practice for ...
Jhun-Chen Chen, Jhun-Chen Chen, Chii-Gong Tong, Chii-Gong Tong, Hsiang-Yin Lin, Hsiang-Yin Lin, Su-Chiung Fang, Su-Chiung Fang   +7 more
doaj   +1 more source

Differential Expression Of Gap Junction mRNAs And Proteins In The Developing Murine Kidney And In Experimentally Induced Nephric Mesenchymes [PDF]

, 1992
The expression of three gap junction (GJ) proteins, alpha-1 (Cx43), beta-1 (Cx32), and beta-2 (Cx26), and their transcripts were examined during the ontogeny of the mouse and rat kidney. These proteins were expressed in two non-overlapping patterns.
Gilbert, Scott F., Gilula, N. B., Kumar, N. M., Lehtonen, E., Nishi, M., Sainio, K., Saxen, L.   +6 more
core   +1 more source

Comparative Analysis of Nuclear Transfer Embryo Derived Mouse Embryonic Stem Cells. Part I: Cellular characterization [PDF]

, 2012
Embryonic stem cells derived from nuclear transfer embryos (ntESCs) are particularly valuable for regenerative medicine, as they are a patient-specific and histocompatible cell source for the treatment of varying diseases.
Csonka, Erika, Dinnyes, Andras, Hadlaczky, Gyula, Kobolak, Julianna, Mamo, Solomon, Rungsiwiwut, Ruttachuk, Ujhelly, Olga   +6 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source