Results 141 to 150 of about 953,645 (368)

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Assessing technical aspects and vulnerabilities from Tswaing informal settlement in Hammanskraal, South Africa

Jàmbá
The increasing frequency of hazards such as floods, droughts, socio-political unrest, emerging diseases and rising temperatures has affected South Africa.
Davies V. Nkosi, Patience Mbola, Evelyn R. Maleka, Dikeledi M. Mapheto, Engetelo P. Ngwenya, Thabang S. Mokwena, Silas Mohlala, Nchang J. Langa, Lethabo S. Kgopa, Octavia M. Komane   +9 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Spatial spread of COVID-19 during the early pandemic phase in Italy

BMC Infectious Diseases
Quantifying the potential spatial spread of an infectious pathogen is key to defining effective containment and control strategies. The aim of this study is to estimate the risk of SARS-CoV-2 transmission at different distances in Italy before the first ...
Valeria d’Andrea, Filippo Trentini, Valentina Marziano, Agnese Zardini, Mattia Manica, Giorgio Guzzetta, Marco Ajelli, Daniele Petrone, Martina Del Manso, Chiara Sacco, Xanthi Andrianou, Antonino Bella, Flavia Riccardo, Patrizio Pezzotti, Piero Poletti, Stefano Merler   +15 more
doaj   +1 more source

An O\u27Neill Institute Briefing Paper: Ebola, the World Health Organization, and Beyond: Toward a Framework for Global Health Security [PDF]

, 2015
The West African Ebola epidemic has demonstrated that the world remains ill-prepared to respond to infectious disease outbreaks. A host of institutions are now reviewing what went wrong, and new institutions are being considered, including an African ...
Friedman, Eric A., Gostin, Lawrence O., Hougendobler, Daniel   +2 more
core   +1 more source

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source

Reasons for encounters, diagnoses, and admission rate among emergency referrals at an urban primary care clinic in Japan: A retrospective cohort study

Journal of General and Family Medicine
Background Comprehensive understanding of emergency referrals (EmR), encompassing reasons for encounters (RFEs) and diagnoses, is crucial for primary care physicians (PCPs).
Yoshinao Satoi, Masato Matsushima, Hiroyoshi Iwata   +2 more
doaj   +1 more source

Beyond the Pandemic – The Justice Emergency

, 2022

openalex   +1 more source

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas, Mauro Monforte, Angel Sanchez‐Montañez, Penélope Romero‐Duque, Elena Pegoraro, Jordi Díaz‐Manera, Dmitry Vlodavets, Lorenzo Maggi, Marco Moscatelli, Adele D‘Amico, Montse Olivé, Jorge Alonso‐Pérez, Giacomo Comi, José Miguel Escudero‐Fernández, Gabriela S. Urcuyo, Anna Pichiecchio, Angela Berardinelli, Kristl G. Claeys, Claudio Bruno, Chiara Panicucci, Sara Bortolani, Eleonora Torchia, Enzo Ricci, Soledad Monges, Jorge A. Bevilacqua, Jorge Diaz‐Jara, Maggie C. Walter, Simone Thiele, Nicoline Løkken, John Vissing, Susana Quijano‐Roy, Robert Y. Carlier, Nicol C. Voermans, Chiara Marini‐Bettolo, Michela Guglieri, Volker Straub, Lea Leonardis, Francina Munell, David Gómez‐Andrés, Giorgio Tasca   +39 more
wiley   +1 more source

Experts' Views on Factors Influencing Resource Allocation for Infectious Disease Emergencies Based on Humanitarian Principles: A Qualitative Study

AJPM Focus
Introduction: Infectious diseases can result in global emergencies and a shortage of resources, leading to ethical and humanitarian challenges. This study aimed to identify the factors that affect the allocation of health resources based on humanitarian ...
Mohammad Reza Fallah Ghanbari, PhDc, Katayoun Jahangiri, PhD, Mehdi Safari, PhD, Zohreh Ghomian, PhD, Mohammad Ali Nekooie, PhD   +4 more
doaj   +1 more source