Results 31 to 40 of about 542,322 (319)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Monitoring of patients with microdialysis following pancreaticoduodenectomy—the MINIMUM study: study protocol for a randomized controlled trial

Trials, 2021
Background Postoperative pancreatic fistula after pancreatoduodenectomy is a much-feared complication associated with substantial mortality and morbidity.
Espen Lindholm, Nil Ekiz, Tor Inge Tønnessen   +2 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Emergence.

Philosophica, 1997
Abstract ‘Emergence’ looks at the relations between building blocks, generated systems, and the phenomenon of emergence. To understand emergent phenomena, it is necessary to describe the emergence of a system’s behaviour from the non-additive interactions of its building blocks. Emergence occurs when the generators for a generated system
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Disseminating information on acute public health events globally: experiences from the WHO’s Disease Outbreak News

BMJ Global Health
WHO works, on a daily basis, with countries globally to detect, prepare for and respond to acute public health events. A vital component of a health response is the dissemination of accurate, reliable and authoritative information.
Ibrahima Socé Fall, Babatunde Olowokure, Oliver Morgan, Masaya Kato, Roberta Andraghetti, Maria Almiron, George Sie Williams, Aura Corpuz, Amarnath Babu, Tshewang Dorji, Tamano Matsui, Ka Yeung Cheng, Lauren E MacDonald, Harsh Lata, Alessandro Miglietta, Eri Togami, Neil Jan Saad Duque, Devin Perkins, Jukka Tapani Pukkila, Carmen Dolea, Abdirahman Mahamud, Adedoyin Awofisayo-Okuyelu, Esther Hamblion   +22 more
doaj   +1 more source

Personal Emergency Alert Device Containing Real-Time Location

International Journal of Computing Sciences Research, 2022
Purpose – The purpose of this study is to develop a Personal Emergency Alert Device Containing Real-time Location which can be used by anyone particularly women and children who need help especially in times of emergency.
Stephanie E. Liwanag, Ma. Andrea A. Alfaro, Wilfred I. Carlos, Jerald B. Cruz, Rea G. Guevarra, Eddiebal P. Layco, Louie Fe S. Villanueva   +6 more
doaj   +1 more source

Analysis of the COVID-19 pandemic: lessons towards a more effective response to public health emergencies [PDF]

, 2022
Yibeltal Assefa, Charles F. Gilks, Simon Reid, Remco van de Pas, Dereje G. Gete, Wim Van Damme   +5 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source