Results 41 to 50 of about 821,456 (332)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Conceptual Design and Parametric Optimization of a New Multileveled Horsetail Structure for Bicycle Helmets

Advanced Engineering Materials, EarlyView., 2023
This study aims to explore the feasibility of using a structure inspired by the features of horsetail and human spine as the potential helmet liner, targeting at mitigation of acceleration‐induced injuries. A parametric study is conducted to investigate the effect of individual geometrical variables in the design, indicating its capability to reduce ...
Bing Leng, Dong Ruan, Shanqing Xu, Kwong Ming Tse   +3 more
wiley   +1 more source

Disseminating information on acute public health events globally: experiences from the WHO’s Disease Outbreak News

BMJ Global Health
WHO works, on a daily basis, with countries globally to detect, prepare for and respond to acute public health events. A vital component of a health response is the dissemination of accurate, reliable and authoritative information.
Ibrahima Socé Fall, Babatunde Olowokure, Oliver Morgan, Masaya Kato, Roberta Andraghetti, Maria Almiron, George Sie Williams, Aura Corpuz, Amarnath Babu, Tshewang Dorji, Tamano Matsui, Ka Yeung Cheng, Lauren E MacDonald, Harsh Lata, Alessandro Miglietta, Eri Togami, Neil Jan Saad Duque, Devin Perkins, Jukka Tapani Pukkila, Carmen Dolea, Abdirahman Mahamud, Adedoyin Awofisayo-Okuyelu, Esther Hamblion   +22 more
doaj   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Topology Optimization of Lattice Support Structure for Cantilever Beams Fabricated Via Laser Powder Bed Fusion

Advanced Engineering Materials, EarlyView., 2023
A numerical scheme is presented to design a lattice support for metallic components additively built via laser powder bed fusion. Results show that thermal‐induced distortion can be respectively reduced by 69%, 58%, and 50% in comparison to a uniform lattice, a fully solid support, and a truss‐based lattice support.
Jiazheng Hu, Marjan Molavi‐Zarandi, Damiano Pasini   +2 more
wiley   +1 more source

СONSTRUCTION AND THE ALGORITHM OPERATION OF THE LASER COMBINED FIRE DETECTOR

Приборы и методы измерений, 2017
The point optical smoke detector is currently the most effective means of fire detection at the early stage of its occurrence. The urgent task for this type of detector is to increase its sensitivity to «black» smoke and ensure resilience to the effects ...
A. I. Kitsak, A. P. Lushchyk, D. L. Esipovich, V. N. Konon, I. V. Kavalchyk, O. A. Protasevich, I. B. Tretyak   +6 more
doaj   +1 more source

Cardiopulmonary resuscitation (CPR) training strategies in the times of COVID-19: a systematic literature review comparing different training methodologies

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2021
Background Traditional, instructor led, in-person training of CPR skills has become more challenging due to COVID-19 pandemic. We compared the learning outcomes of standard in-person CPR training (ST) with alternative methods of training such as hybrid ...
Daniyal Mansoor Ali, Butool Hisam, Natasha Shaukat, Noor Baig, Marcus Eng Hock Ong, Jonathan L. Epstein, Eric Goralnick, Paul D. Kivela, Bryan McNally, Junaid Razzak   +9 more
doaj   +1 more source

Personal Emergency Alert Device Containing Real-Time Location

International Journal of Computing Sciences Research, 2022
Purpose – The purpose of this study is to develop a Personal Emergency Alert Device Containing Real-time Location which can be used by anyone particularly women and children who need help especially in times of emergency.
Stephanie E. Liwanag, Ma. Andrea A. Alfaro, Wilfred I. Carlos, Jerald B. Cruz, Rea G. Guevarra, Eddiebal P. Layco, Louie Fe S. Villanueva   +6 more
doaj   +1 more source

Five minutes with Andrew Miller MP: “It’s important that people handle information in an intelligent way, and social science has a huge role in this” [PDF]

, 2011
In 2011 the Science and Technology Select Committee examined the role of science when emergencies such as the H1N1 influenza pandemic and the volcanic ash disruption occur. Andrew Miller, chair of the Government’s Science and Technology Select Committee,
Blog Admin, Impact of Social Sciences,, Miller, Andrew   +1 more
core  

A Fault-Tolerant Emergency-Aware Access Control Scheme for Cyber-Physical Systems [PDF]

, 2011
Access control is an issue of paramount importance in cyber-physical systems (CPS). In this paper, an access control scheme, namely FEAC, is presented for CPS. FEAC can not only provide the ability to control access to data in normal situations, but also
Lu, Dongze, Wu, Guowei, Xia, Feng, Yao, Lin   +3 more
core   +1 more source