Results 41 to 50 of about 578,848 (315)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Optimal allocation of defibrillator drones in mountainous regions [PDF]

, 2019
Responding to emergencies in Alpine terrain is quite challenging as air ambulances and mountain rescue services are often confronted with logistics challenges and adverse weather conditions that extend the response times required to provide life-saving ...
Hungerländer, Philipp, Kolesnik, Ewald, Korzen, Christopher, Reiner, Gerald, Truden, Christian, Wankmüller, Christian   +5 more
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Emergence.

Philosophica, 1997
Abstract ‘Emergence’ looks at the relations between building blocks, generated systems, and the phenomenon of emergence. To understand emergent phenomena, it is necessary to describe the emergence of a system’s behaviour from the non-additive interactions of its building blocks. Emergence occurs when the generators for a generated system
openaire   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Disseminating information on acute public health events globally: experiences from the WHO’s Disease Outbreak News

BMJ Global Health
WHO works, on a daily basis, with countries globally to detect, prepare for and respond to acute public health events. A vital component of a health response is the dissemination of accurate, reliable and authoritative information.
Ibrahima Socé Fall, Babatunde Olowokure, Oliver Morgan, Masaya Kato, Roberta Andraghetti, Maria Almiron, George Sie Williams, Aura Corpuz, Amarnath Babu, Tshewang Dorji, Tamano Matsui, Ka Yeung Cheng, Lauren E MacDonald, Harsh Lata, Alessandro Miglietta, Eri Togami, Neil Jan Saad Duque, Devin Perkins, Jukka Tapani Pukkila, Carmen Dolea, Abdirahman Mahamud, Adedoyin Awofisayo-Okuyelu, Esther Hamblion   +22 more
doaj   +1 more source

Criteria and components of the emergency and disaster database in Iran: A content analysis study

Journal of Education and Health Promotion, 2021
BACKGROUND: Nowadays, emergencies and disasters are considered one of the biggest problems in human life. To reduce the risk of emergencies and disasters, governments must develop strategies and policies using evidence-based methods.
Sadegh Ahmadi Mazhin, Mehrdad Farrokhi, Mehdi Noroozi, Juliet Roudini, Seyed Ali Hosseini, Mohammad Esmaeil Motlagh, Pirhossein Kolivand, Hamidreza Khankeh   +7 more
doaj   +1 more source

Working as an EMT [PDF]

, 2010
The work of Emergency Medical Technicians (EMTs) is often the difference between life and death for a patient. EMTs respond to various medical emergencies including car accidents, heart attacks, slips and falls of the elderly, childbirth, and gunshot ...
Mietlicki, Robert
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source