Results 51 to 60 of about 140,178 (307)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Effectiveness of escape room–based learning for patient safety education in nursing students
BMC Medical EducationBackground Ensuring patient safety is a cornerstone of nursing practice, and its foundation is established during nursing education. The study evaluates the effectiveness of escape room–based learning designed in accordance with the International Patient
Inangil Demet +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Emergency first aid course [PDF]
, 1970 Governor Frank Farrar, on the left in coat, tie, and glasses, checks into the emergency first aid course, possibly EMT training, sponsored by the state.
University of South Dakota
core
Evaluation of First Aid Knowledge Levels of Elementary Teacher Education Students at a Public University in İstanbul [PDF]
Aim: Children are prone to unexpected accidents and injuries, making emergency preparedness essential in schools. Elementary teachers must be skilled in first aid.
Fatma Burcu Doğanç +7 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Optimizing CPR performance: the role of body composition and ergonomic positioning
BMC Emergency MedicineBackground Quality cardiopulmonary resuscitation (CPR) is associated with improved survival rates in prehospital arrest cases. Although CPR guidelines emphasize compression depth, rate, and recoil, individual anatomical and biomechanical factors ...
Tayfun Aygun +5 more
doaj +1 more source
Can video streaming improve first aid for injured patients? A prospective observational study from Norway [PDF]
Background Video streaming in emergency medical communication centers (EMCC) from caller to medical dispatcher has recently been introduced in some countries. Death by trauma is a leading cause of death and injuries are a frequent reason to contact EMCC.
Idland, Siri +6 more
core +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source