Results 81 to 90 of about 810,633 (307)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The Effect of Etanercept Treatment on the levels of Albumin and C-reactive Protein and their Ratio in Iraqi Psoriatic Patients

مجلة كلية الطب
Background: Psoriasis, a common chronic autoimmune dermatological disease, is identified by scaling and inflammation seen in the skin. Both environmental and genetic factors contribute to its pathogenesis. Objectives: To examine changes in albumin and
Rajaa J. Abdel Rasul , Hathama R. Hasan   +1 more
doaj   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Patient Satisfaction in 112 Emergency Health Services: Scale Development and Validation

Eurasian Journal of Emergency Medicine
Aim: Despite its critical importance, no standardized scale specifically adapted to measure patient satisfaction with all aspects of 112 Emergency Healthcare Services is available.
Emre Karasu, Yunus Emre Öztürk
doaj   +1 more source

Did the WTO Play a Role in the Food Crisis? [PDF]

When high prices or natural calamities result in starvation and political unrest in the developing world emergency food aid is the best short run response.
Meilke, Karl D.
core   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Ensiapukoulutusta Mc Donald'sin henkilökunnalle [PDF]

, 2009
Opinnäytetyönä toteutettiin projekti, jonka avulla A P Eaglefood Oy:n omistamien Mc Donald’s ravintoloiden päälliköt ja kouluttajat saavat työympäristöönsä sopivan ensiapukoulutuksen ja mahdollisuuden päivittää jo olemassa olevia tietojaan.
Mattila, Maarit, Niittylä, Elina, Paronen, Anne   +2 more
core  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Evaluation of stabbing assault injuries in a tertiary emergency department: a retrospective observational study

BMC Emergency Medicine
Background Approximately 458,000 victims were deceased from intentional violence in 2021. A stabbing assault causes 25% of homicides. The study aims to evaluate injury patterns, trauma scores, radiological findings, types of treatment, and outcomes of ...
Nil Deniz Kartal Yeter, Mehmet Ali Karaca, Ahmet Sefa Yeter, Elif Öztürk İnce, Bülent Erbil   +4 more
doaj   +1 more source