Results 51 to 60 of about 11,296,732 (253)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Other title: Local Emergency Planning Committee Handbook

, 2014
application/pdf March 2014This handbook is designed for Local Emergency Planning Committees (LEPCs) in the State of Kansas. This handbook was developed to provide general guidance on LEPC duties, responsibilities and organization.;--Page 11.LEPC ...
Kansas. Division of Emergency Management.
core   +1 more source

Methodology for Transient Stability Assessment and Enhancement in Low-Inertia Power Systems Using Phasor Measurements: A Data-Driven Approach

Mathematics
Modern energy systems are undergoing a profound transformation characterized by the active replacement of conventional fossil-fuel-based power plants with renewable energy sources.
Mihail Senyuk, Svetlana Beryozkina, Ismoil Odinaev, Inga Zicmane, Murodbek Safaraliev   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bulk Power Systems Emergency Control Based on Machine Learning Algorithms and Phasor Measurement Units Data: A State-of-the-Art Review

Energies
Modern electrical power systems are characterized by a high rate of transient processes, the use of digital monitoring and control systems, and the accumulation of a large amount of technological information.
Mihail Senyuk, Svetlana Beryozkina, Murodbek Safaraliev, Andrey Pazderin, Ismoil Odinaev, Viktor Klassen, Alena Savosina, Firuz Kamalov   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Multi-Criteria-Based Key Transmission Section Identification and Prevention–Emergency Coordinated Optimal Control Strategy

Energies
Large-scale blackouts in power systems are often triggered by weak links susceptible to cascading failures. As the concentrated reflection of the system’s weak links, identifying key transmission sections and further implementing safety control measures ...
Xinyu Peng, Chuan He, Honghao Zhang, Lu Nan, Tianqi Liu, Jian Gao, Biao Wang, Xi Ye, Xinwei Sun   +8 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source