Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Emergency preparedness and response in New Zealand schools : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Emergency Management at Massey University, Wellington, New Zealand [PDF]
International disaster risk reduction efforts prioritise school safety. Providing a safe learning environment for students and ensuring their continued access to education after an emergency has a positive influence on student, family, and community ...
Tipler, Karlene Susan
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'Catastrophic Failure' Theories and Disaster Journalism: Evaluating Media Explanations of the Black Saturday Bushfires [PDF]
In recent decades, academic researchers of natural disasters and emergency management have developed a canonical literature on 'catastrophe failure' theories such as disaster responses from from US emergency management services (Drabek, 2010; Quarantelli,
Burns, Alex, Eltham, Ben
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Evolutionary interplay between viruses and R‐loops
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi+4 more
wiley +1 more source
Trusted Emergency Management [PDF]
Abstract : The ability for emergency first responders to access sensitive information for which they have not been pre-vetted can save lives and property. We describe a trusted emergency management solution for ensuring that sensitive information is protected from unauthorized access, while allowing for extraordinary access to be authorized under the ...
Levin, Timothy+5 more
openaire +3 more sources
The Role of Transportation in Campus Emergency Planning, MTI Report 08-06 [PDF]
In 2005, Hurricane Katrina created the greatest natural disaster in American history. The states of Louisiana, Mississippi and Alabama sustained significant damage, including 31 colleges and universities.
Edwards, Frances, Goodrich, Daniel C.
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TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243] [PDF]
Agitated or violent patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians and clinical practice all differ.
A Jablensky+21 more
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There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes+20 more
wiley +1 more source
This chapter is about emergency response planning and crisis management. It addresses the collaborative development and testing of an emergency operations plan (EOP). Key components include active shooter procedures and the advent of the coronavirus (COVID-19) pandemic.
openaire +2 more sources
Wireless E911 Emergency Communications Fund Iowa Homeland Security and Emergency Management Division of the Iowa Department of Public Defense independent auditor's reports, basic financial statements and supplementary information, June 30, 2009. [PDF]
Audit report on the Wireless E911 Emergency Communication Fund of the Iowa Homeland Security and Emergency Management Division of the Iowa Department of Public Defense for the year ended June 30 ...
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