Results 151 to 160 of about 61,831 (226)

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

<b>The RESPONDER trial:</b> a feasibility study of an early intervention model deploying community first responders to administer intranasal naloxone in suspected opioid overdoses in Skåne, Sweden. [PDF]

BMJ Open
Rehn J, Andréll C, Hansson J, Troberg K, Isendahl P, Bråbäck M, Svensson L, Byrsell F, Claesson A, Håkansson A.   +9 more
europepmc   +1 more source

Delicate Management of Alkaline‐Substrate‐Induced Interfacial Reactions Enables High‐Efficiency and Stable Deep‐Red CsPbI3 Perovskite Light‐Emitting Diodes

Advanced Science, EarlyView.
We develop a magnesium‐doping strategy to delicately modulate the alkaline substrate‐induced reactions, ensuring high‐quality CsPbI3 perovskite emissive layers with substantially improved stability. The resultant deep‐red LEDs demonstrate a high peak external quantum efficiency of 23.62% and an exceptional half‐lifetime stability of 376 h at 20 mA cm−2,
Zhennan Tian, Jun Wu, Haifeng Zhao, Yong Yang, Zexi Chen, Tianxiang Lv, Xuehang Chen, Lei Yang, Ding Zheng, Chunyang Yin, Junsheng Yu, Sai Bai   +11 more
wiley   +1 more source

From Ebola to Hantavirus: Spain's Preparedness for High-Consequence Infectious Diseases. [PDF]

Lancet Reg Health Eur
Diago-Navarro E, García-Vaz C, Fanjul G, Naniche D, Almuedo-Riera A, Bassat Q.   +5 more
europepmc   +1 more source

Engineering Ultrastable Intrinsic Radicals: Graphene Quantum Dots With NIR‐II Emission for Dynamic Deep‐Tissue Bioimaging

Advanced Science, EarlyView.
Stable radicals are attractive for photonic and quantum information technologies but are often limited by instability. We stabilize intrinsic radicals in graphene quantum dots via 2D polymerization of perylene derivatives, where bilayer defect confinement suppresses quenching (100–500 K).
Qin Xu, Yijie Hou, Bingzhe Wang, Tesen Zhang, Yupeng Liu, Shuaiqi Li, Maohua Chen, Guichuan Xing, Dongbo Guo, Songnan Qu   +9 more
wiley   +1 more source

Video-supported telephone triage in emergency primary healthcare: an observational study from Norway. [PDF]

BMJ Open
Sandal N, Johansen IH, Hjortdahl M, Baste V, Ness S, Zakariassen E.   +5 more
europepmc   +1 more source

Paraborg: Paramedic Cyborg Insects for In Situ Emergency Drug‐Delivery

Advanced Science, EarlyView.
This work introduces Paraborg, a human‐supervised paramedic cyborg‐insect platform that combines controllable locomotion, onboard imaging, and an auto‐injection mechanism for in situ drug‐delivery. By demonstrating reliable navigation, target stabilization, injector launch, and multi‐insect teamwork, the study extends cyborg insects from survivor ...
H. Nhan Le, P. Thien Phan, Lachlan Fitzgerald, P. Ross McAree, T. Nho Do, T. Thang Vo‐Doan   +5 more
wiley   +1 more source

Strengthening natural hazard preparedness in Nepal: insights from stakeholder and community engagement. [PDF]

Glob Health Action
Bhatta S, Mytton J, Joshi SK, Pant PR, Adhikary P, Adhikari BR, Gautam S, Powell J, Teijlingen EV.   +8 more
europepmc   +1 more source

From Circuits to Symphonies: A Systems‐Engineering Blueprint for Multimicrobial Synthetic Biology

Advanced Science, EarlyView.
Engineering synthetic microbial consortia requires moving beyond intracellular genetic circuits toward coordinated multicellular design. A modular systems‐engineering framework is presented that integrates communication, temporal coordination, ecological structuring, and predictive modeling to guide application‐dependent consortium design ...
Miguel Fernández‐Niño, Ludger A. Wessjohann, José Manuel Guillamón, Daniela Burgos‐Toro, Silvia Moriano‐Gutiérrez, Giacomo Di Matteo, Zia‐ul Islam, Rinke van van Tatenhove‐Pel, Vanessa Rossetto Marcelino, Rodrigo Ledesma‐Amaro   +9 more
wiley   +1 more source

Standardising the preparation for, and delivery of care during, and after critical incidents: a Faculty of Sport and Exercise Medicine position statement. [PDF]

Front Sports Act Living
Heron N, Griffin S.
europepmc   +1 more source