Results 231 to 240 of about 259,467 (345)

Combination vs. single‐drug nonprescription analgesics for acute pain management: A narrative review

British Journal of Clinical Pharmacology, EarlyView.
Combining nonprescription analgesics with different mechanisms of action has been proposed as a rational strategy to optimize the management of acute pain. This review assessed the efficacy and safety of nonprescription analgesics, including paracetamol (acetaminophen), metamizole and nonsteroidal anti‐inflammatory drugs (NSAIDs) used in combination vs.
Ali Mobasheri, Bart Morlion, Vidhu Sood Sethi, Mary Cardosa, Oscar Della Pasqua, Pranab Kalita   +5 more
wiley   +1 more source

A Decision-Analytic Model to Evaluate Cost-Effectiveness of Regional Implementation of a Mobile Stroke Unit. [PDF]

Neurology
van Hulst PL, van de Wijdeven RM, Venema E, Pinckaers FME, Hunink MGM, van der Lugt A, Dippel DWJ, Lingsma HF, Bos D, Roozenbeek B, ICAI Stroke Lab.   +10 more
europepmc   +1 more source

Effect of vepdegestrant, a PROTAC oestrogen receptor degrader, on dabigatran and rosuvastatin pharmacokinetics in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims To evaluate the effects of vepdegestrant, a PROteolysis TArgeting Chimera (PROTAC) oestrogen receptor degrader, on the pharmacokinetics of dabigatran (a P‐glycoprotein [P‐gp] substrate) and rosuvastatin (a breast cancer resistance protein [BCRP] substrate).
Derek Z. Yang, Li Zhou, Jennifer A. Winton, Kyle T. Matschke, Constantino Kantaridis, Kristine Doyle, Kimberly C. Lee, Naihan Chen, Yuanyuan Zhang, Weiwei Tan   +9 more
wiley   +1 more source

Recurrent fexuprazan‐induced liver injury following unintentional re‐exposure

British Journal of Clinical Pharmacology, EarlyView.
Fexuprazan, a potassium‐competitive acid blocker, is increasingly used for the treatment of gastroesophageal reflux disease in South Korea. While generally well tolerated, data regarding its hepatotoxic potential are scarce. We report a case of idiosyncratic drug‐induced liver injury in a 61‐year‐old woman following 2 months of fexuprazan therapy.
Sook Jin Seong, O Seong Kweon, Young‐Ran Yoon, Yu Kyung Kim, Yoo Na Kang, Se Young Jang   +5 more
wiley   +1 more source

Enhancing patient stratification methods for medication review during acute admissions

British Journal of Clinical Pharmacology, EarlyView.
Medication review in the hospital is an effective tool for identifying inappropriate prescribing, but not every patient can receive one due to resource constraints. Thus, it is important to identify patients who stand to benefit most from medication review.
Louise Westberg Strejby Christensen, Helle Gybel Juul‐Larsen, Line Jee Hartmann Rasmussen, Esben Iversen, Kim Peder Dalhoff, Ove Andersen, Morten Baltzer Houlind   +6 more
wiley   +1 more source

Pain Assessment and Its Effect on Pain Management During Emergency Medical Services-A Descriptive Study in the Tampere University Hospital Area of Finland. [PDF]

Acta Anaesthesiol Scand
Lidauer SM, Hoppu S, Kaartinen K, Lidauer MH, Kalliomäki ML.   +4 more
europepmc   +1 more source

The emergency medical service dispatch recommendation system using simulation based on bed availability

Yeong-Yuh Xu, Shao-Jen Weng, Peng Huang, Lee-Min Wang, Chih‐Hao Chen, Yao‐Te Tsai, Ming-Che Tsai   +6 more
openalex   +1 more source

Effectiveness and safety of combining thiazides with loop diuretics vs. loop diuretics monotherapy in patients with acute decompensated heart failure: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study investigated factors associated with and outcomes of combined loop diuretics with hydrochlorothiazide (HCTZ) for acute decompensated heart failure (ADHF). Methods In this retrospective study, adults hospitalized for ADHF and who received intravenous loop diuretics between January 2016 and March 2023 were enrolled.
Chia‐Chen Hsu, Hsien‐Chih Chiu, Ju‐Chieh Wung, Yueh‐Ching Chou, Yuh‐Lih Chang, Chian‐Ying Chou, Chin‐Chou Huang   +6 more
wiley   +1 more source

An innovative curriculum development experience: Emergency Medical Dispatch role in the Healthcare Transformation Vision of Saudi Arabia

‏Yousef Alsofayan, Kharsan Almakhalas, Abdullah Alabdali, Mohammed Arafat, Nawfal Aljerian, Ameera Cluntun, Waad Alshammari, Salman Alharthi, ‏Fahad Alhajjaj, ‏Jalal Alowais, Sami Alsolamy, Bandr Mzahim, Abdulrahman Sabbagh   +12 more
openalex   +1 more source

AZD0449, an inhaled JAK1 inhibitor, in healthy participants and patients with mild asthma

British Journal of Clinical Pharmacology, EarlyView.
Aims Inhaled corticosteroids (ICS) plus bronchodilator are recommended for the treatment of asthma. Targeting the JAK1‐dependent pathway may be an alternative for asthma management in patients with incomplete response to ICS. The aim of this study was to investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of AZD0449, a
Anna Lundahl, Rod Hughes, Joachim Almquist, David Close, Jukka Mäenpää, Ulrika Tehler, Tina Jellesmark Jensen, Szilárd Nemes, Anne‐Kristina Mercier, Zala Jevnikar, Pablo Forte Soto, Dave Singh   +11 more
wiley   +1 more source