Results 231 to 240 of about 209,160 (315)

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj, Chay Ngee Lim, Yinhua Li, Kyle T. Matschke, Richard Bertz, Robert Croop, Jing Liu   +6 more
wiley   +1 more source

Emergency Medical Service Responses for Older Adults: A Retrospective Observational Study Comparing Nursing Homes and the Community. [PDF]

Healthcare (Basel)
Gaik C, Wulf H, Mann V, Humburg D, Vojnar B.   +4 more
europepmc   +1 more source

Results of the ACCOuNT Trial: A Multi‐Institutional Prospective Pharmacogenomics Implementation Trial for African American Inpatients

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacogenomics implementation efforts have increased over the last decade, but no published prospective pharmacogenomics trials have formally evaluated utility in underrepresented populations. We present final results from the ACCOuNT trial, a multi‐institutional prospective study [NCT03225820] in which African American inpatients were genotyped and ...
Zhong Huang, Kevin J. O'Leary, Edith A. Nutescu, Matthew Jack, Thomas Chen, Gregory W. Ruhnke, James C. Lee, David George, Larry K. House, Randall Knoebel, Luke V. Rasmussen, Seth Hartman, Anish Choksi, Kiang‐Teck J. Yeo, Minoli A. Perera, Mark J. Ratain, David O. Meltzer, Peter H. O'Donnell   +17 more
wiley   +1 more source

Recognition of stroke symptoms indicative of anterior circulation large-vessel occlusion via telephone and video calls: a simulation study. [PDF]

BMC Emerg Med
Herrmann ML, Meier S, Schuchardt FF, Henningsen M, Wimmesberger N, Rau D, Farin-Glattacker E, Brich J.   +7 more
europepmc   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta‐Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used for pain and inflammation but are associated with gastrointestinal (GI) bleeding. While this risk is well established, most studies evaluate NSAIDs as a homogenous class, limiting clinical decision‐making based on individual agent safety.
Abdelrahman G. Tawfik, Ainhoa Gomez‐Lumbreras, Guilherme Del Fiol, Kensaku Kawamoto, Katy E. Trinkley, Thomas Reese, Aubrey Jones, Daniel C. Malone   +7 more
wiley   +1 more source

Patient and mission characteristics of helicopter emergency medical services in the Republic of Ireland: a retrospective analysis. [PDF]

Scand J Trauma Resusc Emerg Med
Hennelly D, Masterson S, O'Donnell C, Jennings PA, McHugh S, Quinn R, Deasy C.   +6 more
europepmc   +1 more source

DISTRICTING AND DISPATCHING POLICIES TO IMPROVE THE EFFICIENCY OF EMERGENCY MEDICAL SERVICE (EMS) SYSTEMS

, 2012
Damitha Bandara
openalex   +1 more source

Clinical Implementation of Pharmacogenomics and Drug–Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow‐Up

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel, Filippa Schreeck, Simon Jaeger, Severin Schricker, Elke Schaeffeler, Svitlana Igel, Daniela Steinberger, Manuel Pagitz, Jörg Latus, Markus Ketteler, Kerstin Bühl, Marc‐H. Dahlke, Hans‐Georg Kopp, Matthias Schwab   +13 more
wiley   +1 more source

Prehospital transfusion: an 8-year descriptive retrospective monocenter study. [PDF]

BMC Emerg Med
Coisy F, Corbefin M, Ajavon F, Ceausu D, Lagarrigue M, Markarian T, Muller L, Bobbia X, Grandpierre RG.   +8 more
europepmc   +1 more source

TGFβ Plays a Minimal Role in Supporting Th17 Cell Phenotype Post Differentiation

Barrier Immunity, EarlyView.
ABSTRACT Th17 cells can adopt different functional capabilities in response to environmental stimuli, exhibiting functional plasticity, contributing to both pathogenic autoinflammation but also vital homeostatic immune regulation, particularly at mucosal barriers.
Annie Whelan, Kelly Wemyss, Joshua R. Cox, Rufus Daw, Flora A. McClure, James I. King, Logan Sauers, Hayley M. Bridgeman, Tom McCarthy, John R. Grainger, Joanne E. Konkel   +10 more
wiley   +1 more source