Results 151 to 160 of about 994,865 (303)

The effect of training on the management of nuclear disasters by emergency department nurses and physicians [PDF]

open access: yes
Objective: On account of the widespread use of nuclear energy in different fields, nuclear accidents and disasters have been on a rise. Thus, it is crucial for medical staff especially emergency department personnel to be aware of the nature of these ...
Alireza Ala1 , Farzad Rahmani1* , Reza Aslzad1 , Zahra Parsian1,
core  

Superelastic High‐Entropy Oxide Ceramic Aerogels for Thermal Superinsulation and Sealing at Extreme Conditions

open access: yesAdvanced Science, EarlyView.
A high‐entropy oxide ceramic of (Gd1/2Lu1/2)2(Ti1/3Zr1/3Hf1/3)2O7 is prepared through a molecular synthesis route of pyrolytic solid‐solution reactions. The architectured nanofiber aerogel manifests unprecedented thermomechanical properties, including superelastic compressibility of 98% from −196 to 1500 °C, and thermal superinsulation capacity (24.14 ...
Xiaoke Jiang   +9 more
wiley   +1 more source

All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery

open access: yesAdvanced Science, EarlyView.
Self‐assembling nanoparticles composed entirely of POEGMA are engineered by exploiting side‐chain–dependent amphiphilicity and tunable thermoresponsive behavior. These single‐material nanocarriers encapsulate diverse hydrophobic drugs with high efficiency, retain therapeutic activity, improve in vivo efficacy, and evade anti‐PEG antibodies.
Parul Sirohi   +15 more
wiley   +1 more source

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

open access: yesAdvanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

open access: yesAdvanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu   +7 more
wiley   +1 more source

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