Results 151 to 160 of about 10,862,170 (249)

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer

Advanced Science, EarlyView.
Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian, Tongguan Tian, Zhenxiang Wang, Huihui Sun, Ming Zong, Ying Chen, Jie Xiong, Ye Chen, Zhiqian Hu, Tianming Li, Yanping Xu, Shuchang Xu   +11 more
wiley   +1 more source

The Australian emergency medical system

, 2008
The Australian emergency medical system has transformed over the last thirty years with the development of pre-hospital care services, hospital Emergency Departments and the development of new professional roles of Emergency Physician and Paramedic. This
Hang, H., FitzGerald, Gerard, Hou, Xiang-Yu   +2 more
core  

Status of emergency medical service use for acute ischemic stroke in China. [PDF]

Sci Rep
Qi W, Su Y, Wu J, Shi X, Wu X, Chi F, Xia R, Qin L, Cao L, Yang Y, Liu Q, Peng X, Huang G, Chen J, Xue Y, Guan W, Gao D, Ye B, Yu T, Zhu R, Ren L.   +20 more
europepmc   +1 more source

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

The Danish quality database for prehospital emergency medical services

, 2016
Erika Frischknecht Christensen,1–3 Peter Anthony Berlac,4 Henrik Nielsen,5 Christian Fynbo Christiansen5 1Clinical Institute, Aalborg University, 2Department of Anesthesiology and Intensive Care, Aalborg University Hospital, Aalborg, 3Prehospital ...
Christiansen CF, Berlac PA, Nielsen H, Frischknecht Christensen E   +3 more
core  

Barriers to Helicopter Emergency Medical Service Operations in Nepal: A Retrospective Study of Mission Cancellations. [PDF]

Cureus
Karki S, Bayliss C, Parajuli S, Thakur A, Magar RR, Basnet Y.   +5 more
europepmc   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Reorganisation of the Basic Life Support Segment in a Physician-Led Emergency Medical Service: A Retrospective Evaluation of Operational and Clinical Characteristics. [PDF]

J Clin Med
Friebel J, Manni M, Gozdowsky SC, Brettschneider P, Grün D, Baumann AM, Spielmann E.   +6 more
europepmc   +1 more source

Vine‐Inspired Soft Robotics: Materials, Actuations, and Emerging Applications

Advanced Science, EarlyView.
Vine‐inspired robots grow from the tip, enabling navigation through confined spaces with minimal disturbance. This Review summarizes material and actuation strategies for vine‐inspired growth, key functions including steering, retraction, attachment, branching, and variable stiffness, and emerging applications spanning medical intervention, confined ...
Jiahao Wu, Xingyun Liu, Fangzhou Wang, Huili Ren, Chaojun Zhang, Ziyu Ren, Zunqi Liu, Jing Li   +7 more
wiley   +1 more source

Prehospital emergency medical service missions to nursing homes - a descriptive retrospective register-based study in Southwest Finland. [PDF]

BMC Emerg Med
Myrskykari H, Iirola T, Nordquist H.
europepmc   +1 more source