Results 61 to 70 of about 391,050 (289)

KRAS mRNA Spleen‐Targeting Lipid Nanoparticles Synergize with Irinotecan Silicasomes to Robustly Augment the Cancer Immunity Cycle in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo   +3 more
wiley   +1 more source

Thematic analysis of six Asian prehospital emergency medical systems to explore development principles

open access: yesEmergency and Critical Care Medicine
. Background. Well-designed and functioning emergency medical service (EMS) can provide equitable access to emergency care to improve health issues, especially in low- and middle-income countries where the majority of deaths are due to conditions that ...
Amila Ratnayake   +17 more
doaj   +1 more source

HOW CAN THE PUBLIC BE BETTER PROTECTED AGAINST COVID-19?

open access: yesJurnal Berkala Epidemiologi, 2020
INTRODUCTION The response to the COVID-19 pandemic is a tragic aberration gripping the world. As the disease evolves, uncertainty and fear of harm rise, which can significantly diminish community health and wellbeing.
Connie CR Gan, Febi Dwirahmadi
doaj   +1 more source

A community-based ambulance model: lessons for emergency medical services and everyday health systems resilience from South Africa

open access: yesHealth Policy and Planning
Abstract The role of the emergency medical service (EMS) is changing globally as ambulance crews respond to a shifting burden of disease, as well as societal stressors such as violence and inequality. New ways of thinking about how to provide emergency care are required to shift EMS from a role primarily focused on clinical care and ...
Leanne Brady   +4 more
openaire   +2 more sources

Multi‐Physically Programmable Tubular Origami Metamaterials: Exploitable Nexus of Geometry, Folding Mechanics and Stimuli‐Responsive Physics

open access: yesAdvanced Science, EarlyView.
This article presents an insightful review on the exploitable nexus of geometry, folding mechanics and stimuli‐responsive physics for achieving active programmability in tubular origami metamaterials and metastructures, highlighting the broad‐spectrum potential in innovative applications across the length scales, along with critically analysing the ...
A. Sharma, S. Naskar, T. Mukhopadhyay
wiley   +1 more source

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

open access: yesAdvanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal   +15 more
wiley   +1 more source

O processo comunicativo no serviço de atendimento móvel de urgência (SAMU-192) Proceso de comunicación en el servicio de emergencia móvil (SAMU/192) Communicative process in the mobile emergency service (SAMU/192)

open access: yesRevista Gaúcha de Enfermagem, 2012
Este trabalho objetiva caracterizar o processo comunicativo entre os auxiliares de enfermagem das viaturas de Suporte Básico de Vida do Serviço de Atendimento Móvel de Urgência, a coordenação deste serviço e a Central Única de Regulação Médica de um ...
Maria Claudia dos Santos   +4 more
doaj   +1 more source

An overview of the research evidence on ethnicity and communication in healthcare [PDF]

open access: yes, 2005
• The aim of the present study was to identify and review the available research evidence on 'ethnicity and communication' in areas relevant to ensuring effective provision of mainstream services (e.g.
Clay, Diane   +6 more
core  

Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients. [PDF]

open access: yes, 2018
In December 2017, the National Academy of Neuropsychology convened an interorganizational Summit on Population Health Solutions for Assessing Cognitive Impairment in Geriatric Patients in Denver, Colorado. The Summit brought together representatives of a
Adler, Deb   +38 more
core   +2 more sources

Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity

open access: yesAdvanced Science, EarlyView.
This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu   +8 more
wiley   +1 more source

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