Results 41 to 50 of about 9,931,596 (308)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The SEE-IT Trial: emergency medical services Streaming Enabled Evaluation In Trauma: a feasibility randomised controlled trial

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Background Use of bystander video livestreaming from scene to Emergency Medical Services (EMS) is becoming increasingly common to aid decision making about the resources required.
Cath Taylor, Lucie Ollis, Richard M. Lyon, Julia Williams, Simon S. Skene, Kate Bennett, Matthew Glover, Scott Munro, Craig Mortimer, the SEE-IT Trial Group   +9 more
doaj   +1 more source

Evaluation of tools to assess psychological distress: how to measure psychological stress reactions in citizen responders– a systematic review

BMC Emergency Medicine, 2019
Background Dispatched citizen responders are increasingly involved in out-of-hospital cardiac arrest (OHCA) resuscitation which can lead to severe stress.
Astrid Rolin Kragh, Fredrik Folke, Linn Andelius, Emma Slebsager Ries, Rasmus Vedby Rasmussen, Carolina Malta Hansen   +5 more
doaj   +1 more source

Emergency Medical Services for Children [PDF]

Pediatric Annals, 2021
Evelyn M, Lyons, Paul N, Severin
openaire   +2 more sources

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Pre-hospital management of acute stroke patients eligible for thrombolysis – an evaluation of ambulance on-scene time

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2019
Background Stroke is a leading cause of death and disability with effective treatment, including thrombolysis or thrombectomy, being time-critical for favourable outcomes. While door-to-needle time in hospital has been optimized for many years, little is
Nicolas Drenck, Søren Viereck, Josefine Stokholm Bækgaard, Karl Bang Christensen, Freddy Lippert, Fredrik Folke   +5 more
doaj   +1 more source

EMS operation in a female restricted university, Saudi prospective

International Journal of Emergency Medicine, 2021
This paper was written to explain the process and steps and to describe the experience with building a women-only operated collegiate emergency medical service (EMS) system in the largest women-only university in the world.
Wajdan Alassaf, Sameer Al Hamid, Osama Kentab, Abdullah Al Otaibi, Bandar Al Mufareh   +4 more
doaj   +1 more source

Enhancing Emergency Response through Artificial Intelligence in Emergency Medical Services Dispatching; a Letter to Editor

Archives of Academic Emergency Medicine, 2023
The emergency medical dispatcher (EMD) serves as a crucial link between individuals in need of emergency medical assistance and the emergency medical services (EMS) resource delivery system.
Payam Emami, Karim Javanmardi
doaj   +1 more source

Screening of community-dwelling older patients by the emergency medical services : An observational retrospective registry study [PDF]

, 2021
Background: Inadequate nutrition, falls, and cognitive impairment are common problems among acutely ill older people and are associated with complicated and prolonged health problems and mortality.
Saario, Eeva L., Jämsen, Esa R. K., Castren, Maaret K., Nikander, Pia, Jämsen, Esa R.K., Mäkinen, Marja T.   +5 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source