Results 51 to 60 of about 324,654 (268)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The burden and etiologies of diarrhea in Asia and its countries from 1990 to 2021 and the forecast to 2040: analyses informed by the global burden of disease study 2021

Frontiers in Public Health
BackgroundThis study aimed to analyze the burden, temporal trends and etiologies of diarrhea from 1990 to 2021, and to forecast the burden from 2022 to 2040 in Asia and Asian countries.MethodsData were sourced from the Global Burden of Diseases (GBD ...
Shan Liu, Zhiping Wu, Qingyu An, Jun Wu, Jinjian Bai, Wei Sun, Linan Guo, Luxi Gong   +7 more
doaj   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Purchaser, firearm, and retailer characteristics associated with crime gun recovery: a longitudinal analysis of firearms sold in California from 1996 to 2021

Injury Epidemiology
Background Firearm violence is a major cause of death and injury in the United States. Tracking the movement of firearms from legal purchase to use in crimes can help inform prevention of firearm injuries and deaths. The last state-wide studies analyzing
Sonia L. Robinson, Christopher D. McCort, Colette Smirniotis, Garen J. Wintemute, Hannah S. Laqueur   +4 more
doaj   +1 more source

Research on identification of nucleus-shaped anomaly regions in space electric field

Frontiers in Astronomy and Space Sciences
The presence of nucleus-shaped anomalous regions in the power spectrum image of the electric field VLF frequency band has been discovered in previous studies.
Xing-Su Li, Xing-Su Li, Zhong Li, Zhong Li, Zhong Li, Jian-Ping Huang, Jian-Ping Huang, Ying Han, Ying Han, Yu-Meng Huo, Yu-Meng Huo, Jun-Jie Song, Jun-Jie Song, Bo Hao, Bo Hao   +14 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

TDBOSegNet: A Semantic Segmentation Model for Typical Disaster-Bearing Objects in UAV Images of Flood Disasters: TDBOSegNet:un modèle de segmentation sémantique pour identifier les objets affectés lors d’inondations, à partir d’images de drones

Canadian Journal of Remote Sensing
In recent years, the intensifying effects of climate change have led to an increase in natural disasters, posing significant challenges to ecosystems. Unmanned Aerial Vehicles (UAVs), with their rapid deployment and high flexibility, play a crucial role ...
Yanwei Sui, Weifeng Shan, Maofa Wang, Yu Yang, Mengyu Wang   +4 more
doaj   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Detection Method and Application of Nuclear-Shaped Anomaly Areas in Spatial Electric Field Power Spectrum Images

Remote Sensing
It is found that there are some anomalous high-energy nuclear-shaped regions in the VLF frequency band of the space electric field. To detect and statistically analyze these nuclear-shaped anomaly areas, this paper proposes a nuclear-shaped anomaly area ...
Xingsu Li, Zhong Li, Jianping Huang, Xuming Yang, Wenjing Li, Yumeng Huo, Junjie Song, Ruiqi Yang   +7 more
doaj   +1 more source