Results 71 to 80 of about 2,979,495 (301)
Emerging Activators and Regulators of Inflammasomes and Pyroptosis
Trends in Immunology, 2019 The inflammasome is a cytosolic immune signaling complex that induces inflammation and pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger or homeostasis-altering signals; they can play critical roles in the development of autoinflammatory conditions and cancer.
Xue, Yansong +4 more
openaire +3 more sources
, 1991 application/pdfA set of 18 documents provided by the Kansas Division of Emergency Management with resources and information on Chemical Spill/Radiation Emergency Notifications and the Emergency Planning and Community Right-to-Know Act.Chemical Planning ...
Kansas. Division of Emergency Management.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Regional Power Grid Automatic Generation Control Strategy Considering Energy Storage Participation
发电技术ObjectivesTo address the coordination issue of frequency regulation resources such as energy storage, coal-fired units, and gas-fired units for area regulation requirement (ARR) allocation in power grids, a control strategy considering energy storage ...
LI Xiao +5 more
doaj +1 more source
Legal issues of service and combat activities security forces in social emergency situations
Проблеми Законності, 2015 The analysis of regulatory support service and combat activity of the forces of law and order in social emergency situations is realised. The basic problems are determined for of legal regulation of service and combat activity of the forces of law and ...
В. В. Мацюк
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Extracellular TG2: emerging functions and regulation [PDF]
The FEBS Journal, 2011 Tissue transglutaminase (TG2) is a ubiquitously expressed member of the transglutaminase family of Ca2+‐dependent crosslinking enzymes. Unlike other family members, TG2 is a multifunctional protein, which has several other well documented enzymatic and non‐enzymatic functions.
openaire +2 more sources
Local and tribal emergency managers
, 2018 Began with May 1, 2018Mode of access: Internet from the Oregon Government Publications CollectionText in EnglishIssued by: Oregon Emergency Management, -May 2022; by: Oregon Department of Emergency Management, July 2022-This archived document is ...
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source