Results 181 to 190 of about 3,872,290 (346)

Validation of the emergency surgery score's predictive accuracy for postoperative outcomes and ICU admissions in MENA vs. non-MENA emergency surgery patients. [PDF]

Eur J Trauma Emerg Surg
Ghali MS, Hasan SA, Al-Qudimat AR, Alabidi M, Moustafa OS, Al-Zoubi RM.   +5 more
europepmc   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

The clinical application of shared decision-making in emergency surgery: a scoping review protocol. [PDF]

BMJ Open
Bisset CN, Keane C, McKee T, John-Charles R, Wells CI, Moug SJ.   +5 more
europepmc   +1 more source

Positive Feedback Loop of Histone Lactylation‐Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance

Advanced Science, EarlyView.
Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang, Jiao Chen, En‐Liang Zhu, Ming‐Jian Ma, Yang‐Yin‐Hui Yu, Ying‐Qin Zhu, Jing‐Yuan Ye, Jin‐Zhao Xie, Zi‐Yi Zhao, Xiao‐Yu Yin   +9 more
wiley   +1 more source

Intraoperative peak lactate as a predictor of in-hospital mortality following non-cardiac emergency surgery: a retrospective cohort study. [PDF]

Langenbecks Arch Surg
Fu Y, Zhang Y, Shen L, Huang Y.
europepmc   +1 more source

The great emergency general surgery debate

, 2014

openalex   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Early Prophylactic Anticoagulation and In-Hospital Mortality in Patients with Severe Acute Pancreatitis: A Retrospective Cohort Study

Open Access Emergency Medicine
Haodong Zhao,1,* Hui Liu,1 Jiongjiong Cheng,1 Jia Chen,1 Shuo Li,2 Yaowei Sun,3 Yu Wang4,* 1Department of Emergency Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China ...
Zhao H, Liu H, Cheng J, Chen J, Li S, Sun Y, Wang Y   +6 more
doaj  

Emergency Surgery for Acute Left-Sided Complicated Diverticulitis in the Elderly: What Are the Predictor Factors of Mortality and Morbidity? [PDF]

J Clin Med
Vaccari S, Pirrera B, Ussia A, Lauro A, Minghetti M, Cervellera M, D'Andrea V, Tonini V.   +7 more
europepmc   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source