Results 91 to 100 of about 1,753,814 (314)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Malignant priapism due to penile metastases. Case series and literature review [PDF]

, 2016
Malignant priapism secondary to penile metastases is a rare condition. This term was originally used by Peacock in 1938 to describe a condition of painful induration and erection of the penis due to metastatic infiltration by a neoplasm.
DE DOMINICIS, Carlo, DE LUCA, Francesco, Manzi, Emy, Maurizi, Angela, Ralph, David, Shabbir, Majed, Zacharakis, Evangelos, Zanghì, Antonio   +7 more
core   +2 more sources

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Health Professionals and Public Awareness of Carbon Monoxide Poisoning in Vermont [PDF]

, 2018
Introduction. Carbon monoxide (CO) is the second leading cause of non-medical poisoning death in the United States. Between 1999 and 2012, Vermont saw the highest rates of CO poisoning deaths in New England. Public education and the use of CO alarms have
Carney, Jan, Cubberley, C. Wesley, Delaney, Tom, Hannigan, Julia, Hiromoto, Lee, Hoffman-Contois, Razelle, Irwin, William, Nilo, Michael Carlo, Soderquist, Conner, Stedman, Eleanor   +9 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma [PDF]

, 2013
Background In acute asthma inhaled beta₂-agonists are often administered by nebuliser to relieve bronchospasm, but some have argued that metered-dose inhalers with a holding chamber (spacer) can be equally effective.
Ba, Batra, Beasley, Benton, Berenberg, Burrows, Campbell, Cates, Cates, Chong-Neto, Chou, Coker, Colacone, Deerojanawong, Dewar, Direkwatanachai, Duarte, Fayaz, Ferrés, Freelander, Fuglsang, Gleeson, Hodder, Idris, Jasper, Kaashmiri, Kerem, Leversha, Levitt, Lin, Lipworth, Madsen, Maguire, Maldano-Alanis, Mandelberg, Mandelberg, Morgan, Morley, Morrone, Newman, Newman, Osmond, Parkin, Pendergast, Ploin, Ploin, Powell, Raimondi, Rao, Robertson, Rodrigo, Rodrigo, Rodrigo, Rowe, Rubilar, Salzman, Schuh, Shaikh, Shim, Sirikul, Summer, Tarala, Turner, Turner, Valencia, Vangveeravong, Vazquez Cordero, Vilarinho, Vivek, Wildhaber, Williams   +70 more
core   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

A pH-Triggered antibacterial and lubricating dual-function hydrogel coating for infection-resistant urinary catheters

Frontiers in Bioengineering and Biotechnology
IntroductionUrinary catheterization frequently causes urinary tract infections and patient discomfort. While hydrogel coatings combining antibacterial and hydrophilic properties offer a potential solution, challenges such as uncontrolled antimicrobial ...
Ming Cheng, Weijie Lin, Weijie Lin, Weijie Lin, Jianbo Yu, Peiliang Gao, Fange Shi, Chunyu Wang, Yong Ma, Zhongdi Liu, Zhongdi Liu, Zhongdi Liu, Guiying Dong   +12 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Outcome measurements in patients with a lumbar disc herniation – a scoping review

Brain and Spine
Introduction: Outcome measurement is a cornerstone of modern medicine. A range of tools are commonly used for outcome assessment in lumbar disc herniation (LDH) treatment.
N. Gabrovsky, M. Petrov, Y. Kotceva, Y. Petrova   +3 more
doaj   +1 more source