Results 131 to 140 of about 12,409,837 (292)

Infection prevention and treatment following dog bites: a systematic review of randomized controlled trials [PDF]

open access: yesJournal of Trauma and Injury
Purpose Dog bites pose a significant global public health challenge, with outcomes that range from minor injuries to fatalities. Despite their prevalence, no consensus has been established regarding the most effective prevention and treatment strategies.
Yongsik Yoon   +4 more
doaj   +1 more source

Sex‐Related Differences in Efficacy and Safety Outcomes in Axial Spondyloarthritis Randomized Clinical Trials: A Systematic Literature Review and Meta‐Analysis

open access: yesArthritis Care &Research, EarlyView.
Objective We aimed to assess differences in baseline characteristics, efficacy, and safety of advanced therapies between male and female patients with axial spondyloarthritis (axSpA) in randomized controlled trials (RCTs). Methods We conducted a systematic literature search for RCTs assessing the efficacy of advanced therapies in patients with axSpA ...
Angel Gao   +5 more
wiley   +1 more source

Sequence Analysis to Phenotype Healthcare Patterns in Adults with Musculoskeletal Conditions Using Primary Care Electronic Health Records

open access: yesArthritis Care &Research, Accepted Article.
Objective The aim of this study was to apply sequence analysis (SA) to phenotype healthcare patterns of adult patients with musculoskeletal (MSK) conditions using primary care electronic health records and to investigate the association between these healthcare patterns and post‐consultation patient's self‐reported outcome.
Smitha Mathew   +6 more
wiley   +1 more source

Intervention effects based on potential benefit [PDF]

open access: yesarXiv
Optimal treatment rules are mappings from individual patient characteristics to tailored treatment assignments that maximize mean outcomes. In this work, we introduce a conditional potential benefit (CPB) metric that measures the expected improvement under an optimally chosen treatment compared to the status quo, within covariate strata.
arxiv  

Endovascular treatment with Onyx of arterio-venous fistula around the transverse sinus presenting with ocular symptoms. Case report

open access: yesInterdisciplinary Neurosurgery
Introduction: Dural arterio-venous fistulas /DAVF/ are rare vascular malformations that represent around 10–15% of all intracranial vascular malformations.
N. Velinov   +5 more
doaj  

Considering the Risks and Costs of Solid Organ Xenotransplantation

open access: yesAdvanced Biology, EarlyView.
This perspective discusses the rationale, risks, and costs of whole‐organ xenotransplantation. It considers alternative strategies to obviate the demand for transplants and optimize allotransplantation systems and practices that do not impose xenotransplantation's harms and risks, and whether they are the most ethical and effective means to increase ...
Catharine E. Krebs   +5 more
wiley   +1 more source

Depletion of TP53 in Human Pluripotent Stem Cells Triggers Malignant‐Like Behavior

open access: yesAdvanced Biology, EarlyView.
Human pluripotent stem cells (hPSCs) with TP53‐depleting mutations are generated, mimicking commonly occurring events in vitro. Loss of TP53 does not alter pluripotency status or in vitro differentiation potential but causes genetic instability and transcriptome changes and confers superior clonal and anchorage‐free growth and higher chemotherapeutic ...
Joaquin Montilla‐Rojo   +9 more
wiley   +1 more source

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