Results 51 to 60 of about 1,736,582 (363)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Pulpectomy vs. Pulpotomy as Alternative Emergency Treatments for Symptomatic Irreversible Pulpitis—A Multicenter Comparative Randomised Clinical Trial on Patient Perceptions

Clinics and Practice, 2023
Aim: There needs to be more general agreement on the most effective treatment for the emergency patient with Symptomatic Irreversible Pulpitis (SIP). This equivalence randomised clinical study compared the clinical efficiency, as an urgent treatment, of ...
Guillem Esteve-Pardo, Pedro Barreiro-Gabeiras, Lino Esteve-Colomina   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Antidote application: an educational system for treatment of common toxin overdose [PDF]

, 2017
Poisonings account for almost 1% of emergency room visits each year. Time is a critical factor in dealing with a toxicologic emergency. Delay in dispensing the first antidote dose can lead to life-threatening sequelae.
Brusic, V., Chitkushev, L., Long, J., Zhang, G., Zhang, Y.   +4 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

CARE-PACT: a new paradigm of care for acutely unwell residents 
in aged care facilities [PDF]

, 2015
Describes the Comprehensive Aged Residents Emergency and Partners in Assessment, Care and Treatment (CARE-PACT) program: a hospital substitutive care and demand management project that aims to improve, in a fiscally efficient manner, the quality of care ...
Ellen Burkett, Ian Scott
core  

Endotracheal Metastasis Causing Airway Obstruction [PDF]

, 2020
Endotracheal metastasis, a critical complication of primary lung cancer, is an extremely rare lesion. A 73-year-old woman who had previously received treatment for lung cancer presented to our emergency department with dyspnea.
Fujiwara, Takashi, Mizuta, Masanobu, Yano, Yudai   +2 more
core  

Characteristics and costs of individuals experiencing severe hypoglycaemia requiring emergency ambulance assistance in the community [PDF]

, 2012
Background and aims: Hypoglycaemia causes considerable a burden to individuals the healthcare providers. The aim of this study was to examine clinical characteristics of individuals requiring emergency medical assistance by ambulance services for an ...
Davies, Melanie J., Fisher, Harriet, Iqbal, Mohammad, Khunti, Kamlesh, Paul, Sanjoy, Siriwardena, A. Niroshan   +5 more
core   +1 more source

Endovascular treatment with Onyx of arterio-venous fistula around the transverse sinus presenting with ocular symptoms. Case report

Interdisciplinary Neurosurgery
Introduction: Dural arterio-venous fistulas /DAVF/ are rare vascular malformations that represent around 10–15% of all intracranial vascular malformations.
N. Velinov, M. Petrov, T. Sakelarova, P. Yordanov, I. Martinov, N. Gabrovsky   +5 more
doaj   +1 more source

Contact chemical burn of the hand caused by xylene: A case report

Journal of the American College of Emergency Physicians Open, 2020
The use of household cleaners during non‐commercial cleaning applications is a very common task, and the chemical makeup of the cleaning solutions vary as much as their applications do.
Zachary Ewan Dewar, Gregory Christiansen
doaj   +1 more source