Results 41 to 50 of about 79,542 (344)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Die Bedeutung der familiären Lernumwelt für Vorläufer schriftsprachlicher Kompetenzen im Vorschulalter

Journal of Family Research, 2012
The acquisition of reading competencies as a significant cultural skill in our society is initiated early on and supported by a child’s interaction with its social surroundings.
Simone Lehrl, Susanne Ebert, Hans-Günther Roßbach, Sabine Weinert   +3 more
doaj   +1 more source

Presenting complex ideas using simple syntax in fiction for low-literate immigrant adults [PDF]

, 2012
Manuscript based on this conference presentation Vainikka, A. and M. Young-Scholten. 2012. Presenting complex ideas using simple syntax in fiction for low-literate immigrant adults. Presentation a the Second Language Research Forum, Pittsburgh. October.
Vainikka, Anne Marjatta
core   +1 more source

'Datafication': Making sense of (big) data in a complex world [PDF]

, 2013
This is a pre-print of an article published in European Journal of Information Systems. The definitive publisher-authenticated version is available at the link below.
Chen H, Davenport TH, Lavalle S, Mark Lycett, Normann R, Pirolli P, Shah S, Thaler RH, Wilkinson L   +8 more
core   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Accuracy of Diagnostic Codes and Algorithms Used to Identify Rheumatoid Arthritis and Juvenile Idiopathic Arthritis in Administrative Claims and Electronic Health Records: Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective This systematic review aimed to assess the diagnostic accuracy of algorithms used to identify rheumatoid arthritis and juvenile idiopathic arthritis in electronic health records. Methods We searched Medline, Embase, and Cochrane Central Register for Controlled Trials databases and included studies that validated case definitions against a ...
Constanza Saka‐Herrán, Jessica Bennett, Yara Alkabti, Muhammad Fatir, Barbara Clyne, Caroline McCarthy, Gráinne Tynan, Nikki Dunne, Michelle Flood, Eoghan McCarthy, Frank Moriarty   +10 more
wiley   +1 more source

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

The ARCH model: a neuroevolutionary framework for behavioral execution

Frontiers in Psychiatry
Behavior arises from the convergence of multiple constraints rather than single causes. The ARCH × Φ model formalizes this process as a computational grammar of behavior, in which Archetype (A), Drive (D), and Culture (C) interact multiplicatively, and ...
Tahir Rahman, Charles F. Zorumski, J. Reid Meloy   +2 more
doaj   +1 more source

'Should conditionals be emergent ...': asyndetic conditionals in English and German as a Challenge to Grammaticalization Research [PDF]

, 2010
The present article examines asyndetic or conjunctionless conditionals in German and English. According to Jespersen’s Model (1940), this construction arose diachronically from a paratactic discourse sequence with a polar interrogative, but more recently
Van den Nest, Daan
core   +1 more source