Results 101 to 110 of about 1,764,888 (296)

UNDERSTANDING DISABILITIES WITHIN SIBLING RELATIONSHIPS THROUGH EMERGING ADULTHOOD

, 2023
Sibling relationships, one of the most important relationships an individual can have, plays a significant role during childhood, adolescence, and adulthood.
NC DOCKS at East Carolina University, Bryant, Kayla   +1 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Communication during emerging adulthood

, 2012
Young adulthood has always held a prominent place in the study of families and family communication. Young adulthood has traditionally been seen as a period of individual transition and union formation that was accompanied by vast changes in family ...
Arnett, Jeffrey J., Willoughby, Brian J.
core   +1 more source

Adolescent physical activity profiles as determinants of emerging adults’ physical activity

International Journal of Behavioral Nutrition and Physical Activity
Background Although adolescent physical activity (PA) tracks into adulthood, it is unclear if the context of PA practiced during adolescence predicts adult PA.
Mathieu Bélanger, Marie-Andrée Giroux, Pierre Philippe Wilson Registe, François Gallant, Salma Jemaa, Pierre Faivre, Daniel Saucier, Saïd Mekari   +7 more
doaj   +1 more source

Navigating loneliness: the interplay of social relationships and coping skills

International Journal of Adolescence and Youth
This study explores the (characteristics of) social relationships and coping efforts that protect emerging adults from feeling lonely. The research question is ‘what do emerging adults need in order to not feel lonely?’.
Eric Cornelis Schoenmakers, Tina ten Bruggencate   +1 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Four statuses of adulthood: adult roles, psychosocial maturity and identity formation in emerging adulthood

, 2014
Background The main aim of the study was to identify differences pertaining to sense of adulthood, exploration, and commitment dimensions between groups of subjects differing in respect of the number of fulfilled adulthood roles and the level of ...
Joanna Pietrzak, Anna Izabela Brzezińska, Konrad Piotrowski   +2 more
core   +1 more source