Results 121 to 130 of about 7,314,464 (305)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
CellsThe liver is a primary metabolic hub and a pivotal target for gene therapy, owing to its capacity for protein secretion, role in metabolic homeostasis and immune tolerance.
Valentin Artemyev +9 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Dielectric constant of MgO tunnel barrier with epitaxial strain
NPG Asia MaterialsMgO tunnel barrier is a key material in spintronics. MgO-based magnetic tunnel junctions (MTJs) are widely used in magnetic sensors and magnetoresistive random access memory (MRAM) applications.
Tomohiro Nozaki +6 more
doaj +1 more source
Reassortment Dynamics: Phylogeography and Evolution of H4N9 Influenza Viruses
PathogensA characteristic feature of influenza A viruses is their high capacity for reassortment, significantly increasing their genetic diversity. This can lead to the formation of influenza A virus variants with unique phenotypic characteristics, particularly ...
Nataliia A. Bobrova +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Stepping into the future: the power of Big Data and emerging technologies
, 2023 In the twenty-first century, as we enter an era of unprecedented technological innovation and data proliferation, we are not merely stepping; we are leaping into the future.
Marku, Elona +2 more
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Controlling the Microstructure and Strain in Chiral 2D Perovskites by Additive Engineering
Advanced Photonics ResearchThe growing demand for advanced data storage and signal processing technologies has intensified the search for novel materials with tunable optical and electronic properties.
Olga Lozhkina +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source