Results 61 to 70 of about 6,631,258 (288)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Multi-messenger emission characteristics of blazars

Frontiers in Astronomy and Space Sciences
Multi-messenger observations and theories of astrophysical objects are rapidly becoming a critical research area in the astrophysics scientific community. In particular, point-like objects such as BL Lacertae (BL Lac) objects, flat-spectrum radio quasars (FSRQs), and blazar candidates of uncertain type (BCUs) are of distinct interest to researchers ...
Ronald Gamble, Ronald Gamble, Ronald Gamble, Jordan Forman, Amethyst Barnes, Gokul Srinivasaragavan, Gokul Srinivasaragavan, Isiah Holt, Isiah Holt, Marvin Jones, Marvin Jones   +10 more
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

MitigatePlus: Research for low-emission food systems

, 2023
MitigatePlus: Research for Low-Emission Food Systems is one of the Research Initiatives in CGIAR’s new research portfolio that will deliver science and innovation to transform food, land, and water systems in a climate crisis.
Verchot, Louis; Zhang, Wei, http://orcid.org/0000-0002-2933-6275 Zhang, Wei   +1 more
core  

Emission characteristics of methane point sources at coal mines in Shanxi Province based on Gaofen-5 satellite

Meitan xuebao
Methane is one of the long-lived greenhouse gases, with a global warming potential 28 times that of carbon dioxide, accounting for about 16% of the global warming effect.
Hanshu KANG, Kai QIN, Fan LU, Wei HU, Qing XU, Jason Blake COHEN   +5 more
doaj   +1 more source

A fully integrated isoprenoid emissions model coupling emissions to photosynthetic characteristics [PDF]

Plant, Cell & Environment, 2014
AbstractThe lack of a mechanistic basis has hampered modelling isoprene emission responses to environmental drivers, in particular the simulation of isoprene emissions under different CO2 concentrations. Here, we advance previous semi‐mechanistic model formulations by introducing a model that explicitly links electron availability for other purpose ...
GROTE, RÜDIGER, MORFOPOULOS, CATHERINE, NIINEMETS, ÜLO, SUN, ZHIHONG, KEENAN, TREVOR F, PACIFICO, FEDERICA, BUTLER, TIM   +6 more
openaire   +4 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Exploring the feasibility of dimethyl ether (DME) and LPG fuel blend for small diesel engine: A simulation perspective

International Journal of Renewable Energy Development
There is a looming global crisis owing to the increase in greenhouse gases and the escalating fossil fuel process.  The issue is further compounded by the ongoing conflicts in different places in the world. Hence, there is an urgent need for a bouquet of
Thoai Anh Nguyen, Thi Yen Pham, Huu Cuong Le, Van Giao Nguyen, Lan Huong Nguyen   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source