Results 111 to 120 of about 1,380,005 (303)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The Thermal Properties of Solar Flares Over Three Solar Cycles Using GOES X-ray Observations

open access: yes, 2012
Solar flare X-ray emission results from rapidly increasing temperatures and emission measures in flaring active region loops. To date, observations from the X-Ray Sensor (XRS) onboard the Geostationary Operational Environmental Satellite (GOES) have been
A. Kim Tolbert   +17 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu   +11 more
wiley   +1 more source

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker   +9 more
wiley   +1 more source

The Kinematics and Ionization of Nuclear Gas Clouds in Centaurus A

open access: yes, 2013
Neumayer et al. established the existence of a blue-shifted cloud in the core of Centaurus A, within a few parsecs of the nucleus and close to the radio jet.
Bicknell, Geoffrey V.   +2 more
core   +1 more source

Air emissions inventory of the public transport in maracaibo municipality. Part 1: Passenger car

open access: yesRevista Técnica de la Facultad de Ingeniería, 2010
The first phase of mobile source emission inventory based on the 2001 census (specifically, passenger car) for the Maracaibo Municipality, is presented in this work.
Analí Machado   +6 more
doaj  

Analysis of the Energy Potential of Hazelnut Husk Depending on the Variety

open access: yesEnergies
Interest in bioenergy, in particular the use of biomass, has increased significantly in recent years due to increasing climate and economic concerns. As one of the key renewable energy sources, biomass plays an important role in the new energy framework.
Anna Borkowska   +3 more
doaj   +1 more source

Measurement of methane emissions from abandoned oil and gas wells in Hillman State Park, Pennsylvania

open access: yesCarbon Management, 2018
Abandoned oil and gas wells, improperly plugged or unplugged, present a risk to current and future oil and gas development because they provide a potential pathway for unwanted gas and fluid migration to the surface.
Natalie J. Pekney   +7 more
doaj   +1 more source

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro   +10 more
wiley   +1 more source

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