Results 71 to 80 of about 2,853,725 (351)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Organic Molecules in Low-Mass Protostellar Hot Cores: Submillimeter Imaging of IRAS 16293-2422
, 2004 Arcsecond-resolution spectral observations toward the protobinary system IRAS 16293-2422 at 344 and 354 GHz were conducted using the Submillimeter Array. Complex organic molecules such as CH3OH and HCOOCH3 were detected.
Ceccarelli C. +13 more
core +2 more sources
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
South Asia anthropogenic ammonia emission inversion through assimilating IASI observations [PDF]
Atmospheric Chemistry and PhysicsAmmonia has attracted significant attention due to its pivotal role in the ecosystem and its contribution to the formation of secondary aerosols. Developing an accurate ammonia emission inventory is crucial for simulating atmospheric ammonia levels and ...
J. Xia +6 more
doaj +1 more source
Cities, traffic, and CO2: A multidecadal assessment of trends, drivers, and scaling relationships [PDF]
, 2015 Emissions of CO2 from road vehicles were 1.57 billion metric tons in 2012, accounting for 28% of US fossil fuel CO2 emissions, but the spatial distributions of these emissions are highly uncertain.
Gately, Conor K. +2 more
core +1 more source
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Global deposition of total reactive nitrogen oxides from 1996 to 2014 constrained with satellite observations of NO2 columns [PDF]
, 2017 Reactive nitrogen oxides (NOy) are a major constituent of the nitrogen deposited from the atmosphere, but observational constraints on their deposition are limited by poor or nonexistent measurement coverage in many parts of the world.
Geddes, Jeffrey A., Martin, Randall V.
core +1 more source
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
Atmosphere, 2021 Volatile organic compounds (VOCs) are known to play an important role in tropospheric chemistry, contributing to ozone and secondary organic aerosol (SOA) generation.
Hyeonji Lee +3 more
doaj +1 more source