Results 121 to 130 of about 262,930 (273)

In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by modulators

British Journal of Pharmacology, Volume 182, Issue 24, Page 6063-6080, December 2025.
Background and Purpose Cystic fibrosis (CF) is due to loss‐of‐function variants of the CF transmembrane conductance regulator (CFTR) channel. The most effective treatment for people with CF carrying the F508del mutation is the triple combination of elexacaftor–tezacaftor–ivacaftor (ETI).
Emanuela Pesce, Valeria Tomati, Valeria Capurro, Mariateresa Lena, Cristina Pastorino, Miro Astore, Serdar Kuyucak, Benoit Chevalier, Elvira Sondo, Federico Cresta, Alice Dighero, Vito Terlizzi, Cristina Fevola, Stefano Costa, Maria Cristina Lucanto, Valeria Daccò, Laura Claut, Francesca Ficili, Benedetta Fabrizzi, Renata Bocciardi, Federico Zara, Carlo Castellani, Luis J. V. Galietta, Shafagh A. Waters, Alexandre Hinzpeter, Nicoletta Pedemonte   +25 more
wiley   +1 more source

A Catalog of Broad Hα and Hβ Active Galactic Nuclei in MaNGA

The Astrophysical Journal
Broad H α and H β emission lines (FWHM > 1000 km s ^−1 ) are incredibly efficient tracers of the high-velocity clouds encircling active galactic nuclei (AGNs).
James Negus, Julia M. Comerford, Francisco Müller Sánchez   +2 more
doaj   +1 more source

6C radio galaxies at z~1: The influence of radio power on the alignment effect

, 2003
Powerful radio galaxies often display enhanced optical/UV continuum emission and extended emission line regions, elongated and aligned with the radio jet axis.
Baum, Best, Best, Best, Chambers, Cimatti, Inskip, Inskip, Katherine J. Inskip, Malcolm S. Longair, Osterbrock, Philip N. Best   +11 more
core   +1 more source

From cells to pixels: A decision tree for designing bioimage analysis pipelines

Journal of Microscopy, Volume 300, Issue 3, Page 384-408, December 2025.
Abstract Bioimaging has transformed our understanding of biological processes, yet extracting meaningful information from complex datasets remains a challenge, particularly for biologists without computational expertise. This paper proposes a simple general approach, to help identify which image analysis methods could be relevant for a given image ...
Elnaz Fazeli, Robert Haase, Michael Doube, Kota Miura, David Legland   +4 more
wiley   +1 more source

Chandra Detects Low-luminosity Active Galactic Nucleus with MBH = 104–106 M⊙ in Nearby (z < 0.5) Dwarf and Star-forming Galaxies

The Astrophysical Journal
We searched the Chandra and XMM archives for 900 Green Pea galaxies to identify signs of active galactic nuclei (AGN). Green peas are low-mass, emission-line galaxies that resemble high-redshift dwarf galaxies. From 29 observations, we detected X-rays in
Mainak Singha, Julissa Sarmiento, Sangeeta Malhotra, James E. Rhoads, L. Y. Aaron Yung, Junxian Wang, Zhen-Ya Zheng, Ruqiu Lin, Keunho Kim, Jialai Kang, Santosh Harish   +10 more
doaj   +1 more source

Relativistic jets in narrow-line Seyfert 1 galaxies. New discoveries and open questions

EPJ Web of Conferences, 2013
Before the launch of the Fermi satellite only two classes of AGNs were known to produce relativistic jets and thus emit up to the γ-ray energy range: blazars and radio galaxies, both hosted in giant elliptical galaxies.
D’Ammando F., Orienti M., Finke J., Larsson J., Giroletti M.   +4 more
doaj   +1 more source

Physical properties of z~4 LBGs: differences between galaxies with and without Ly-alpha emission

, 2007
We have analysed the physical properties of z~4 Lyman Break Galaxies observed in the GOODS-S survey, in order to investigate the possible differences between galaxies where the Ly-alpha is present in emission, and those where the line is absent or in ...
A. Fontana, A. Grazian, Bouwens, Bruzual, C. De Santis, Cowie, Dickinson, Dickinson, Drory, E. Giallongo, Fontana, Fontana, Fontana, Fujita, Gawiser, Giavalisco, Grazian, Grazian, Hansen, Iwata, Iye, Kashikawa, Keel, L. Pentericci, Lai, Le Fevre, Leitherer, Madau, Malhotra, Mori, Ouchi, Ouchi, P. Santini, Papovich, Rhoads, S. Gallozzi, S. Salimbeni, Shapley, Shapley, Steidel, Steidel, Steidel, Tapken, Thommes, Vanzella, Vanzella, Venemans, Venemans   +47 more
core   +1 more source

Visionaries and Crackpots, Maniacs and Saints: Existential Risk and the Politics of Longtermism

Ratio, Volume 38, Issue 4, Page 268-278, December 2025.
ABSTRACT Despite advancing strong claims about our collective priorities, longtermism has received little attention in debates in political philosophy. I first provide an account of longtermism that highlights the way it departs from established work on intergenerational justice.
Alex McLaughlin
wiley   +1 more source

Emission-Line Galaxies from the HST PEARS Grism Survey I: The South Fields

, 2009
We present results of a search for emission-line galaxies in the Southern Fields of the Hubble Space Telescope PEARS (Probing Evolution And Reionization Spectroscopically) grism survey.
Alighieri, S. D. S., Cohen, S. H., Gardner, J. P., Grogin, N., Gronwall, C., Hathi, N. P., Jansen, R. A., Malhotra, S., Meurer, G. R., Panagia, N., Pasquali, A., Pirzkal, N., Rhoads, J., Straughn, A. N., Walsh, J., Windhorst, R. A., Xu, C.   +16 more
core   +1 more source

Quantification of Perturbation to the Daytime Lower Ionosphere From a Gamma Ray Burst Using ELF Remote Sensing

Geophysical Research Letters, Volume 52, Issue 22, 28 November 2025.
Abstract On 9 October 2022, a powerful gamma ray burst (GRB), GRB221009A, caused significant changes in the electron density of the lower ionosphere, as evidenced by VLF (3–30 kHz) radio wave observations. However, GRB221009A did not yield any observable signatures at the Schumann resonances (∼8, ∼14 Hz), which are also sensitive to the lower ...
M. Gołkowski, Z. Nieckarz, J. Mlynarczyk, M. Ostrowski, J. Kubisz, A. Michalec, J. Lichtenberger, A. Klekociuk, P. Nicholson   +8 more
wiley   +1 more source