Results 81 to 90 of about 199,190 (345)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

First Detection of Shock Waves in RRc Stars

The Astrophysical Journal
Although shock waves have been well documented in fundamental-mode RRab stars, their existence in first-overtone pulsator stars, RRc stars, has remained uncertain. Building upon the spectroscopic frameworks established by M. Chadid et al., we present the
Junzhang Li, Merieme Chadid
doaj   +1 more source

High Spectral Resolution Observations of the Massive Stars in the Galactic Center

, 2005
We present high-resolution near-infrared spectra, obtained with the NIRSPEC spectrograph on the W. M. Keck II Telescope, of a collection of hot, massive stars within the central 25 arcseconds of the Galactic center.
Andrea M. Gilbert, Angelle Tanner, Diane Gilmore, Donald F. Figer, E. E. Becklin, Eckart A., Fransisco Najarro, Genzel R., Harry I. Teplitz, Ian S. McLean, James E. Larkin, James R. Graham, Mark Morris, Moneti A., N. A. Levenson, Najarro F., Ott T., Pott J., Rolf P. Kudritzki   +18 more
core   +3 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

A Comprehensive Analysis of Rovibrational CO in the Era of JWST

The Astronomical Journal
We present an analysis of CO rovibrational emission lines in the 183 infrared spectra of nearby Class II objects obtained with the NIRSPEC instrument on the Keck II telescope over the past two decades.
D. Annie Dickson-Vandervelde, Colette Salyk, Geoffrey A. Blake, Clara Ross, Adwin Boogert, Klaus Pontoppidan   +5 more
doaj   +1 more source

Molecular gas and stars in the translucent cloud MBM 18 (LDN 1569)

, 2012
Seven of ten candidate H-alpha emission-line stars found in an objective grism survey of a 1 square degree region in MBM 18, were observed spectroscopically. Four of these have weak H-alpha emission, and 6 out of 7 have spectral types M1-M4V. One star is
Brand, J., Magnani, L., Wouterloot, J. G. A.   +2 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Mira Variable Stars From LAMOST DR4 Data: Emission Features, Temperature Types, and Candidate Selection

, 2017
Based on an extensive spectral study of a photometrically confirmed sample of Mira variables, we find a relationship between relative Balmer emission-line strength and spectral temperature of O-rich Mira stars.
de Grijs, Richard, Deng, Licai, Liu, Chao, Matsunaga, Noriyuki, Yao, Yuhan   +4 more
core   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source