Results 41 to 50 of about 259,705 (249)

Implementation of a dry deposition module (DEPAC v3.11_ext) in a large eddy simulation code (DALES v4.4) [PDF]

Geoscientific Model Development
High-resolution data on reactive nitrogen deposition are needed to inform cost-effective policies. Large eddy simulation models coupled to a dry deposition module present a valuable tool for obtaining these high-resolution data. In this paper we describe
L. Geers, R. Janssen, G. Thorkelsdottir, G. Thorkelsdottir, G. Thorkelsdottir, J. Vilà-Guerau de Arellano, M. Schaap   +6 more
doaj   +1 more source

Controllable Introduction of Surface Defects on CH₃NH₃PbI₃ Perovskite

Nanomaterials, 2022
One of the unique characteristics of semiconductors is the strong dependence of their properties on crystal defects and doping. However, due to the species diversity and low density, it is very difficult to control the type and concentration of the ...
Sushu Wan, Yajie Zhu, Daocheng Hong, Yuxi Tian   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Satellite-Derived Estimate of City-Level Methane Emissions from Calgary, Alberta, Canada

Remote Sensing
Cities are important sources of anthropogenic methane emissions. Municipal governments can play a role in reducing those emissions to support climate change mitigation, but they need information on the emission rate to contextualize mitigation actions ...
Zhenyu Xing, Thomas E. Barchyn, Coleman Vollrath, Mozhou Gao, Chris Hugenholtz   +4 more
doaj   +1 more source

A methane emissions reduction equivalence framework for alternative leak detection and repair programs

Elementa: Science of the Anthropocene, 2019
Fugitive methane emissions from the oil and gas sector are typically addressed through periodic leak detection and repair surveys. These surveys, conducted manually using handheld leak detection technologies, are time-consuming.
Thomas A. Fox, Arvind P. Ravikumar, Chris H. Hugenholtz, Daniel Zimmerle, Thomas E. Barchyn, Matthew R. Johnson, David Lyon, Tim Taylor   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Performance investigation of two stage Organic Rankine Cycle (ORC) architectures using induction turbine layouts in dual source waste heat recovery

Energy Conversion and Management: X, 2020
Improvement in performance of Organic Rankine Cycle (ORC) systems, particularly in the context of dual heat sources such as IC engines, leads to better return on investments.
Anandu Surendran, Satyanarayanan Seshadri   +1 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source