Results 101 to 110 of about 172,662 (282)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

A joint model for the emission and absorption properties of damped Lyman alpha absorption systems

, 2008
The recently discovered population of ultra-faint extended line emitters can account for the majority of the incidence rate of Damped Lyman Alpha systems (DLAs) at z ~ 3 if the line emission is interpreted as Ly alpha.
Bouché, Brocklehurst, Bryan, Bunker, Carroll, Christensen, Cooke, Dijkstra, Eisenstein, Ellison, Fabian, Fynbo, Fynbo, Gardner, Gardner, Gardner, Haehnelt, Haehnelt, Hinshaw, Jedamzik, Johansson, Kennicutt, Kereš, Kulkarni, Kulkarni, Le Delliou, Luke A. Barnes, Maller, Maller, Martin G. Haehnelt, Nagamine, Nagamine, Pettini, Press, Prochaska, Prochaska, Prochaska, Péroux, Rauch, Razoumov, Sheth, Storrie-Lombardi, Storrie-Lombardi, Warren, Wild, Wolfe, Wolfe, Wolfe, Wolfe, Zwaan   +49 more
core   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

The Effects of Water Temperature on Discharge and Uniformity Parameters of Emitters with Different Discharges, Types and Distances

Journal of Agricultural Sciences, 2017
The research was conducted on emitter testing bench established in Irrigation laboratory, Suleyman Demirel University, Isparta, Turkey. In the study, discharge equations q= kHx , standard temperature discharge index TDI, standard temperature is 20 oC ...
Muhammet Sabit Ilkhan, Ulas Senyıgıt
doaj  

Research on modern radar emitter modelling technique under complex electromagnetic environment

The Journal of Engineering, 2019
Since many modern multi-functional radars emitting dense complex signals are applied in the complex electromagnetic environment, it is challenge to classify and identify the radar emitters in the electronic reconnaissance field.
Chunhong Zhang, Yuetao Han, Ping Zhang, Guanglei Song, Changqing Zhou   +4 more
doaj   +1 more source

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Suppression of local decay rate through energy quantum confinement effect in non-Markovian waveguide QED

PhotoniX
Waveguide quantum electrodynamics (QED) system manifests an ideal platform for studying many-body physics. When multiple emitters are coupled to a common waveguide, subradiant states may arise because of the waveguide-mediated interaction, leading to a ...
Yuan Liu, Hong-Bo Sun, Linhan Lin
doaj   +1 more source

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro, María Victoria Zelaya, Hasier Eraña, Javier Sánchez Ruiz de Gordoa, Fermín García‐Amigot, Anika Simonovska‐Serra, María Cristina Caballero, Isidre Ferrer, Ellen Gelpi, Ivonne Jericó, Joaquín Castilla   +10 more
wiley   +1 more source