Results 111 to 120 of about 791,174 (331)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Improving Processability and Efficiency of Resonant TADF Emitters: A Design Strategy

Advanced Optical Materials, 2019
A new design strategy is introduced to address a persistent weakness with resonance thermally activated delayed fluorescence (R‐TADF) emitters to reduce aggregation‐caused quenching effects, which are identified as one of the key limiting factors.
David Hall, S. Suresh, P. L. dos Santos, Eimantas Duda, S. Bagnich, A. Pershin, P. Rajamalli, D. Cordes, A. Slawin, D. Beljonne, A. Köhler, I. Samuel, Y. Olivier, E. Zysman‐Colman   +13 more
semanticscholar   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Photon emissions from Kerr equatorial geodesic orbits

European Physical Journal C: Particles and Fields
We consider the light emitters moving freely along the geodesics on the equatorial plane near a Kerr black hole and study the observability of these emitters.
Yanming Su, Minyong Guo, Haopeng Yan, Bin Chen   +3 more
doaj   +1 more source

Study of the time and space distribution of beta+ emitters from 80 MeV/u carbon ion beam irradiation on PMMA

, 2012
Proton and carbon ion therapy is an emerging technique used for the treatment of solid cancers. The monitoring of the dose delivered during such treatments and the on-line knowledge of the Bragg peak position is still a matter of research.
A. Di Domenico, A. Paoloni, A. Sarti, A. Sciubba, Agodi, Agostinelli, Allison, Amaldi, C. Agodi, C. Voena, E. De Lucia, E. Iarocci, F. Bellini, F. Collamati, F. Ferroni, F. Romano, Fiedler, Fiedler, G. Cuttone, G.A.P. Cirrone, I. Mattei, Jan, L. Piersanti, M. De Napoli, M. Marafini, P. Gauzzi, Parodi, Pawelke, Priegnitz, Pshenichnov, R. Faccini, S. Fiore, Sommerer, V. Patera, Vecchio   +34 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Loss-tolerant architecture for quantum computing with quantum emitters [PDF]

Quantum
We develop an architecture for measurement-based quantum computing using photonic quantum emitters. The architecture exploits spin-photon entanglement as resource states and standard Bell measurements of photons for fusing them into a large spin-qubit ...
Matthias C. Löbl, Stefano Paesani, Anders S. Sørensen   +2 more
doaj   +1 more source

Deterministic integration of quantum dots into on-chip multi-mode interference beamsplitters using in-situ electron beam lithography

, 2017
The development of multi-node quantum optical circuits has attracted great attention in recent years. In particular, interfacing quantum-light sources, gates and detectors on a single chip is highly desirable for the realization of large networks.
Bounouar, Samir, Burger, Sven, Heindel, Tobias, Höhne, Theresa, Park, Suk-In, Reitzenstein, Stephan, Rodt, Sven, Ryu, Geun-Hwan, Schall, Johannes, Schnauber, Peter, Song, Jin-Dong   +10 more
core   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source