Results 101 to 110 of about 403,054 (297)
Identifying Tipping Points during Healthy Brain Aging through Single‐Nucleus Transcriptomic Analysis
Advanced Science, EarlyView.This study applies single‐nucleus transcriptomics and systems dynamics to uncover nonlinear aging patterns in healthy human brains. By introducing dynamic network biomarker theory, the authors identify a critical tipping point at ages 56–60 during aging, and highlight glial instability as a key mediator.
Peiru Wu +9 more
wiley +1 more source
The Testimony of Heart Disease to the Sensory Facies of the Emotions. [PDF]
, 1896 C. L. Herrick
openalex +1 more source
Advanced Science, EarlyView.Macrophages infiltrate the spinal cord post‐injury, decreasing over time. Microglia phagocytose myelin debris, increasing lipid accumulation. Macrophage deletion improves outcomes, while microglial deletion worsens them. The LD+ microglia subtype shows abnormal Pparg signaling.
Mingran Luo +17 more
wiley +1 more source
The Rôle of the Parasympathetics in Emotions. (Psychol. Rev., vol. xl, p. 368, July, 1933.) Kling, C. [PDF]
, 1934 G. W. T. H. Fleming
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Dynamic Neural Deactivation Bridges Direct and Competitive Inhibition Processes
Advanced Science, EarlyView.Dynamic neural deactivation bridges traditionally distinct inhibitory mechanisms—direct inhibition and competition‐induced inhibition—revealing a common neural signature across modalities. Multimodal neuroimaging and behavioral experiments demonstrate a temporal dynamic characterized by progressive frontoparietal activation decay and enhanced sensory ...
Zhenhong He +6 more
wiley +1 more source
Integration of Genetic and Imaging Data for Alzheimer's Disease Diagnosis and Interpretation
Advanced Science, EarlyView.AlzCLIP is a novel contrastive learning framework that integrates single nucleotide polymorphism (SNP) profiles and MRI‐derived imaging features into a unified representation space to improve Alzheimer's disease (AD) diagnosis and interpretation. By achieving superior diagnostic accuracy and revealing key genetic and structural contributors to AD risk,
Yanfei Wang +7 more
wiley +1 more source
The Impact of Design Factors on Drivers’ and Non-Drivers’ Comprehension of Variable Message Signs
Behavioral SciencesThis study examines differences in comprehension between drivers and non-drivers when interpreting variable message signs (VMSs) combining three elements—a pictogram, an arrow, and a city name—to indicate temporary traffic events (e.g., “congestion ...
Ana Hernando +3 more
doaj +1 more source
Feelings and Emotions: the Wittenberg Symposium [PDF]
, 1929 Alfred Adler, Martin L. Reymert
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Advanced Science, EarlyView.Plasma proteomics is leveraged to decode the biological underpinnings of chronic widespread pain. A nested machine learning framework integrates proteomic signatures, prospective outcomes, and Mendelian randomization to uncover 18 causal proteins.
Li Chen +16 more
wiley +1 more source