Results 161 to 170 of about 1,176,885 (307)

Combining CD34+ stem cell selection with prophylactic pathogen and leukemia directed T‐cell immunotherapy to simultaneously reduce graft versus host disease, infection, and leukemia recurrence after allogeneic stem cell transplant

open access: yesAmerican Journal of Hematology, Volume 98, Issue 1, Page 159-165, January 2023., 2023
Donor stem cell product undergoes CD34 stem cell selection. CD34 positive stem cells are used for transplantation. Pathogen‐ and leukemia‐specific T‐cells are manufactured from CD34 negative fraction and infused prophylactically 21 days after transplant.
David J. Gottlieb   +12 more
wiley   +1 more source

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

open access: yesAdvanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin   +7 more
wiley   +1 more source

Photo‐Biomodulation of the Hippocampus Using Near‐Infrared Laser to Enhance Cognitive Function in Mice

open access: yesAdvanced Science, EarlyView.
Here a transcranial photo‐biomodulation approach is developed using near‐infrared (NIR) laser on hippocampus of mice, revealing significant improvements in learning and memory ability of mice under normal and disease conditions. The improvement results from the high‐density cell‐induced NIR local energy deposition, neuronal activation, and axonogenesis
Wei‐Tong Pan   +6 more
wiley   +1 more source

EFO: the Emotion Frame Ontology [PDF]

open access: yesarXiv
Emotions are a subject of intense debate in various disciplines. Despite the proliferation of theories and definitions, there is still no consensus on what emotions are, and how to model the different concepts involved when we talk about - or categorize - them.
arxiv  

Emotionally interactive agents [PDF]

open access: yes, 2018
Models in language processing have researched how words are interpreted by humans. Many models presume the ability to correctly interpret the beliefs, motives and intentions underlying words.
Iza-Miqueleiz, Mauricio
core  

Microneedle Patch for In Situ Neutrophil Monitoring

open access: yesAdvanced Science, EarlyView.
An in situ chromogenic microneedle patch that achieves daily blood neutrophil monitoring without vascular invasion or laboratory apparatus is developed. The detection ability is well demonstrated in a chemotherapy‐induced neutropenic rat model and can be read out using a mobile phone application.
Ziyi Lu   +26 more
wiley   +1 more source

Core Components of Emotional Impulsivity: A Mouse-Cursor Tracking Study [PDF]

open access: yesarXiv
Impulsive individuals exhibit abnormal reward processing (heightened preference for immediate rewards, i.e., impulsive choice, IC) and a penchant for maladaptive action (the inability to inhibit inappropriate actions, i.e., impulsive action, IA). Both impulsive choice and impulsive action are strongly influenced by emotions (emotional impulsivity); yet
arxiv  

Oxytocin‐Mediate Modulation of Splenic Immunosuppression in Chronic Social Stress Through Neuroendocrine Pathways

open access: yesAdvanced Science, EarlyView.
Chronic social stress elevates oxytocin levels, leading to immunosuppression by enhancing regulatory T‐cell activity and promoting anti‐inflammatory macrophage polarization in the spleen. Blocking oxytocin signaling reverses these effects but worsens stress‐induced behavioral disorders and reduces survival rates. This highlights oxytocin's dual role in
Yi‐Shu Zhang   +5 more
wiley   +1 more source

Teaching perspectives on the communication of difficult news of genetic conditions to medical students

open access: yesAmerican Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 299-305, January 2023., 2023
Abstract Informing parents that their child has a diagnosis of Down syndrome (DS) is a common example of the delivery of unexpected or difficult news. Expectations and life planning will change, and if detected prenatally, discussions might include the option of pregnancy termination.
Ashley M. Vanasse   +8 more
wiley   +1 more source

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