VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source
Advanced Science, EarlyView.Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan +10 more
wiley +1 more source
The effectiveness of emotion-focused therapy on distress tolerance, fear of positive experience, and psychosomatic symptoms in individuals experiencing grief due to COVID-19 [PDF]
فصلنامه ابن سیناBackground and aims: Deaths caused by the coronavirus have complicated the grieving process, often leading to unexpressed or complicated grief with severe and long-lasting consequences.
Maryam Bahraminia +2 more
doaj
A Comparison of the Effectiveness of Emotion-Focused Couple Therapy and Acceptance and Commitment Therapy on Attachment Behavior in Marital Relationships among Women with Marital Conflicts [PDF]
پژوهشهای کاربردی روانشناختیThe objective of this investigation was to evaluate the efficacy of effectiveness of emotion-focused couple therapy and acceptance and commitment therapy in influencing the attachment behavior of women experiencing marital conflicts. The pretest-posttest
Mahnaz Esmaeili +2 more
doaj +1 more source
Cognitive psychopathology: The role of emotion [PDF]
, 2009 This paper examines the role of emotion in the understanding of psychopathology. The influential Cognitive Therapy model of Beck is briefly reviewed and a number of limitations are considered.
Power, Michael J., Power, M.
core
Advanced Science, EarlyView.Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo +10 more
wiley +1 more source
An Exploration of Emotion Regulation in Psychosis [PDF]
, 2009 The emotional experience of individuals who experience psychosis has historically been neglected, possibly due to the divide between the psychoses and neuroses.
Harper, Sean +2 more
core +1 more source
Advanced Science, EarlyView.NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu +10 more
wiley +1 more source
The Effectiveness of Emotion Focused Couple Therapy on Dyadic Adjustment, Attachment Security, and Marital Relationship Quality in Couples with Extramarital Relationships [PDF]
مطالعات روانشناختیThe purpose of this study was to investigate the effectiveness of emotion focused couple therapy on dyadic adjustment, attachment security, and marital relationship quality in couples with extramarital relationships.
Fahime Ghafourian Mohebi +3 more
doaj +1 more source
Family-focused cognitive behaviour therapy versus psycho-education for chronic fatigue syndrome in 11- to 18-year-olds: a randomized controlled treatment trial [PDF]
, 2010 Background - Only one previous randomized controlled trial (RCT) has examined the efficacy of cognitive behaviour therapy (CBT) for chronic fatigue syndrome (CFS) in children.
Deary, V. +7 more
core +1 more source