Results 81 to 90 of about 110,107 (264)

Sleep disturbances in the prodromal phase of mood episodes in patients with bipolar disorder: a replicated single-case design

Journal for Person-Oriented Research
This study aims to examine whether objectively measured sleep disturbances occur in the prodromal phase of mood episodes in patients with bipolar disorder.
Stefan Knapen, Evelien Snippe, Arnout C. Smit, Robert A. Schoevers, Rixt F. Riemersma-van der Lek   +4 more
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Disentangling comorbidity: symptom dimensions of internalizing and functional disorders in a large general population sample

BMC Psychiatry
Background Internalizing disorders (IDs) and functional disorders (FDs) are highly comorbid, however the mechanisms underlying their co-occurrence remain unclear.
Urvi Saini, Steven H. Aggen, Albertine J. Oldehinkel, Judith G. M. Rosmalen, Hanna M. van Loo   +4 more
doaj   +1 more source

Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing

Advanced Science, EarlyView.
Wearable sweat sensing relies not only on chemical detection but also on controlled biofluid management. This Review integrates sweat physiology, induction strategies, and microfluidic sampling architectures, demonstrating how flux, transport, and refreshment shape measurement reliability.
Soyoung Shin, Wei Gao
wiley   +1 more source

A qualitative study exploring early experiences of misophonia through firsthand perspectives

Frontiers in Psychiatry
IntroductionMisophonia is characterized by highly aversive affective, physiological, and behavioral responses to specific auditory and related cues. Although research on misophonia has increased in recent years, relatively little is known about onset ...
Emily C. Gates, Alyssa Gabbidon, Grace A. Heppes, M. Zachary Rosenthal, M. Zachary Rosenthal   +4 more
doaj   +1 more source

Dyadic Emotion Regulation

Annual Review of Psychology
A robust approach to understanding dyadic emotion regulation needs to incorporate insights from affective science and relationship science. To date, research emerging from these two traditions has largely unfolded separately with limited cross-disciplinary collaboration.
Beyzanur, Arican-Dinc, Shelly L, Gable
openaire   +2 more sources

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

Help-seeking behaviors among Chinese people with mental disorders: a cross-sectional study

BMC Psychiatry, 2019
Background Failure to seek treatment for mental health disorders is a serious public health concern. Unfortunately, there is little insight into help-seeking and its associated factors in China which has undergone rapid economic development in the past ...
Huifang Yin, Klaas J. Wardenaar, Guangming Xu, Hongjun Tian, Robert A. Schoevers   +4 more
doaj   +1 more source