Results 41 to 50 of about 745,436 (297)

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang   +9 more
wiley   +1 more source

The Mediating Role of Early Maladaptive Schemas in the Relationships of Emotional Maltreatment and Emotional Disorders [PDF]

open access: yes, 2017
Although the consequences of emotional maltreatment have not been extensively investigated, experiences of emotional maltreatment or abuse have been associated with powerful and enduring psychological problems.
Abdolahzadeh Rafi, Mahdi   +2 more
core   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

open access: yesAdvanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du   +5 more
wiley   +1 more source

The Role of Religion as a Mediator between Emotional Abuse and Emotional Disorders in Adolescents [PDF]

open access: yesRavānshināsī-i Afrād-i Istis̠nāyī, 2014
The present study intended to determine the extent to which religion is significant as a mediator between emotional abuse and emotional disorders in adolescents, and it followed a correlational research design.
Mehdi Abdollahzadeh Rafi
doaj  

Depression Mediates the Association Between Childhood Emotional Abuse and the Onset of Type 2 Diabetes: Findings From German Multi-Cohort Prospective Studies

open access: yesFrontiers in Psychiatry, 2022
BackgroundThe dysregulation of glucose homeostasis via mental health stress is increasingly acknowledged, whereby depression independently increases the risk of the onset of type 2 diabetes by up to 60%.
Seryan Atasoy   +13 more
doaj   +1 more source

Clarifying the Effects of Parental Substance Abuse, Child Sexual Abuse, and Parental Caregiving on Adult Adjustment [PDF]

open access: yes, 2000
Parental alcoholism, childhood sexual abuse, and other forms of child maltreatment are generally viewed as contributing to adult adjustment problems. The long-term effects of these various factors, however, are actually not well understood.
Melchert, Timothy
core   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

open access: yesAdvanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao   +8 more
wiley   +1 more source

Emotional abuse towards children by schoolteachers in Aden Governorate, Yemen: A cross-sectional study

open access: yesBMC Public Health, 2012
Background Emotional abuse is central to other forms of abuse. The primary objective of this paper was to estimate the prevalence of emotional abuse among pupils in basic education schools and the risk factors associated with it in Aden governorate ...
Ba- Saddik Amal S S, Hattab Abdullah S
doaj   +1 more source

Total Estimated Cost of Child Abuse and Neglect in the United States [PDF]

open access: yes, 2007
Outlines the direct and indirect costs of addressing the physical, emotional, social, and cognitive impact of abuse and neglect on the victims, including health care, child welfare services, law enforcement, special education, and lost ...
Ching-Tung Wang, John Holton
core  

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen   +12 more
wiley   +1 more source

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