Results 71 to 80 of about 123,753 (311)

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

open access: yesAdvanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao   +8 more
wiley   +1 more source

Men with intellectual disabilities with a history of sexual offending: empathy for victims of sexual and non-sexual crimes [PDF]

open access: yes, 2014
Background: The objectives were (a) to compare the general empathy abilities of men with intellectual disabilities (IDs) who had a history of sexual offending to men with IDs who had no known history of illegal behaviour, and (b) to determine whether men
Baron-Cohen   +82 more
core   +1 more source

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

open access: yesAdvanced Science, EarlyView.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao   +4 more
wiley   +1 more source

“And in some cases, we're the best option:” A qualitative study of community‐based doula support for black perinatal mental health

open access: yesAmerican Journal of Community Psychology, EarlyView.
Abstract We explored community‐based doulas' perspectives on the acceptability of using formal screening tools to address low rates of mental health screening, diagnosis, and treatment for perinatal anxiety and depression among Black women. Using thematic analysis, we analyzed interview data from 30 community‐based doulas who support Black families ...
Tamara Nelson   +5 more
wiley   +1 more source

Differential roles of EA‐TRAPed cells in the anterior cingulate cortex across various intervention times in inflammatory pain

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The cumulative effect of EA analgesia is partially attributed to the activation of EA‐TRAPed cells in ACC. Multiple EA sessions and single EA sessions activated different neuronal populations in the ACC. The enhanced analgesic effect of multiple EA sessions may be attributed to an increase in the proportion of GABAergic neurons within the ACC. Abstract
Zi Guo   +8 more
wiley   +1 more source

Moving beyond neurophobia to cultivate the neuroquisitive learner

open access: yesAnatomical Sciences Education, EarlyView.
Abstract “Neurophobia,” a pervasive fear of the neurological sciences, poses a significant barrier in medical education, affecting learners and physicians worldwide. Its consequences are far‐reaching, contributing to a limited neurology workforce and diminished confidence among non‐specialists in managing neurological conditions.
Joanna R. Appel   +1 more
wiley   +1 more source

The Minds of Black Women — Impacts on Mental Health and Well-Being Across Collective Identities and Experience [PDF]

open access: yes, 2020
Limited research investigates how structural and institutional barriers affect Black women's mental health. Further, stereotypes and tropes such as the Angry Black Woman and Strong Black Woman are impactful. Black women's proximity to wellness is largely
Campbell, Kayla
core  

Mapping dynamic interactions among cognitive biases in depression [PDF]

open access: yes, 2020
Depression is theorized to be caused in part by biased cognitive processing of emotional information. Yet, prior research has adopted a reductionist approach that does not characterize how biases in cognitive processes such as attention and memory work ...
Bernstein, Amit   +3 more
core   +1 more source

Parental Stress and Caregiver Role Modulate Child–Caregiver Prosodic Synchrony in Autism: A Computational Analysis

open access: yesAutism Research, EarlyView.
ABSTRACT Parental stress influences parent–child interactions in typical development and is a prognostic factor of autism outcome. However, we still do not know to what extent parental stress affects parent–child interactions and whether caregiver role matters.
Maria Grazia Logrieco   +11 more
wiley   +1 more source

Effectiveness of emotional schema therapy on death attitude and distress tolerance of breast cancer patients [PDF]

open access: yesTaḥqīqāt-i ̒Ulūm-i Raftārī, 2023
Aim and Background: Breast cancer is the most common malignancy in women, and despite medical advances and the development of treatments, this disease continues to cause psychological and physical effects on the life dimensions of many affected people ...
Gholamreza Talebi   +3 more
doaj  

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