Results 151 to 160 of about 317,548 (356)

Predominance of Ferroptotic Cell Death Mechanisms in Substantia Nigra Neurodegeneration in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng, Anusha Jayaraman, Richard Reynolds, Jia Nee Foo   +3 more
wiley   +1 more source

The Clash Between Christianity and the Concept of Genius in Roman Society

Forum Theologicum Sardicense
This study offers a critical examination of the complex conflict between early Christianity and the Roman conception of Genius—a foundational spiritual and ideological construct that permeated the social, religious, and political fabric of the Roman ...
Stoycho Staykov
doaj   +1 more source

Synergistische Entwicklungsstrategien von Inhibitoren gegen humane UDP‐Galactose‐4‐Epimerase

Angewandte Chemie, EarlyView.
Die Epimerase GalE ist essenziell für die Biosynthese von krebsrelevanten O‐GalNAc Glykanen. Wir verwenden orthogonales, strukturbasiertes Screening niedermolekularer Fragmente an, um kovalente und nichtkovalente Inhibitoren gegen GalE mit nicht mehr als 22 optimierten Verbindungen zu erhalten.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Crafting divine personae in Julian’s Oration 7 [PDF]

, 2015
Peer reviewedPublisher ...
Greenwood, David Neal
core  

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Dr. Hans Kohn and the political takeover of the Berlin Medical Society by the National Socialist regime in 1933

The Anatomical Record, EarlyView.
Abstract To solidify their power over society, totalitarian regimes will usually eliminate any dissent, any perceived threats early on. These threats include not only political enemies but also educated and independent segments of society, such as professional associations.
Michael Hortsch
wiley   +1 more source

Osteological correlates of the respiratory and vascular systems in the neural canals of Mesozoic ornithurines Ichthyornis and Janavis

The Anatomical Record, EarlyView.
Abstract In birds, the neural canal houses a variety of anatomical structures including the spinal cord, meninges, spinal vasculature, and respiratory diverticula. Among these, paramedullary diverticula and the extradural dorsal spinal vein may leave behind osteological correlates in the form of pneumatic foramina and fossae, and a bilobed geometry of ...
Jessie Atterholt, M. Grace Burton, Mathew J. Wedel, Juan Benito, Ellen Fricano, Daniel J. Field   +5 more
wiley   +1 more source

Origin, evolution and biogeographic dynamics of the European rabbit (Oryctolagus cuniculus) in Southwestern Europe

The Anatomical Record, EarlyView.
Abstract The Pleistocene is a key period for understanding the evolutionary history and palaeobiogeography of the European rabbit (Oryctolagus cuniculus). The species was first documented in southeastern Iberia at the beginning of the Middle Pleistocene and appears to have rapidly spread throughout Southwestern Europe, where it was found in numerous ...
Maxime Pelletier
wiley   +1 more source

Compound Heterozygosity for Hemoglobin S and Hemoglobin LuLu Island

American Journal of Hematology, EarlyView.
Dana Lewis, Thomas Lofaro, Laura Fraser, Sheana Wijemanne, Barbara J. Bain   +4 more
wiley   +1 more source

Challenges and Opportunities in Multi‐Method Integrated Geophysical Prospection of Buried Building Remains at the Sanctuary of Olympia

Archaeological Prospection, EarlyView.
ABSTRACT Ancient Olympia was one of the most important sanctuaries and the venue for the Olympic Games in Greek and Roman times. Its remains are located in the Olympia Terrace (Peloponnese, Greece) at the present‐day confluence of the rivers Alpheios and Kladeos at the base of Mount Kronos.
Sarah Bäumler, Dennis Wilken, Peter Fischer, Lena Slabon, Timo Willershäuser, Birgitta Eder, Hans‐Joachim Gehrke, Erofili‐Iris Kolia, Franziska Lang, Oliver Pilz, Andreas Vött   +10 more
wiley   +1 more source