Results 51 to 60 of about 64,973 (290)

Predicting appropriateness of antibiotic treatment among ICU patients with hospital-acquired infection

npj Digital Medicine
Antimicrobial resistance is a rising global health threat, leading to ineffective treatments, increased mortality and rising healthcare costs. In ICUs, inappropriate empiric antibiotic therapy is often given due to treatment urgency, causing poor ...
Ella Goldschmidt, Ella Rannon, Daniel Bernstein, Asaf Wasserman, Michael Roimi, Anat Shrot, Dan Coster, Ron Shamir   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Effect of Inadequate Initial Empiric Antimicrobial Treatment on Mortality in Critically Ill Patients with Bloodstream Infections: A Multi-Centre Retrospective Cohort Study.

PLoS ONE, 2016
Hospital mortality rates are elevated in critically ill patients with bloodstream infections. Given that mortality may be even higher if appropriate treatment is delayed, we sought to determine the effect of inadequate initial empiric treatment on ...
Rachel D Savage, Robert A Fowler, Asgar H Rishu, Sean M Bagshaw, Deborah Cook, Peter Dodek, Richard Hall, Anand Kumar, François Lamontagne, François Lauzier, John Marshall, Claudio M Martin, Lauralyn McIntyre, John Muscedere, Steven Reynolds, Henry T Stelfox, Nick Daneman   +16 more
doaj   +1 more source

Empiric guideline-recommended weight-based vancomycin dosing and mortality in methicillin-resistant Staphylococcus aureus bacteremia: a retrospective cohort study

BMC Infectious Diseases, 2012
Background No studies have evaluated the effect of guideline-recommended weight-based dosing on in-hospital mortality of patients with methicillin-resistant Staphylococcus aureus bacteremia.
Hall Ronald G, Giuliano Christopher A, Haase Krystal K, Hazlewood Kathleen A, Frei Chistopher R, Forcade Nicolas A, Brouse Sara D, Bell Todd, Bedimo Roger J, Alvarez Carlos A   +9 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Foam used during EPB tunnelling in saturated sand, parameters determining foam consumption [PDF]

, 2012
The amount of foam injected during drilling with an EPB-shield in saturated sand is quite often based on experience and/or empiric relations. A method is presented in to calculate the amount of foam needed to create a muck with limited or no grain stress.
Bezuijen, Adam
core   +1 more source

Non-stationary heat conduction in one-dimensional chains with conserved momentum

, 2009
The Letter addresses the relationship between hyperbolic equations of heat conduction and microscopic models of dielectrics. Effects of the non-stationary heat conduction are investigated in two one-dimensional models with conserved momentum: Fermi-Pasta-
A. V. Savin, Alexander V. Savin, C. Cattaneo, Oleg V. Gendelman, P. Heino, P. Vernotte   +5 more
core   +1 more source

Hydrodynamics of galactic dark matter [PDF]

, 2001
We consider simple hydrodynamical models of galactic dark matter in which the galactic halo is a self-gravitating and self-interacting gas that dominates the dynamics of the galaxy.
Baltz E A, Battaner E, Berezhiani Z G, Boehm C, Burkert A, Burns S D, Cho Y M, Covi L, Dalcanton J J, Dar$iacute$o Nu$ntilde$ez, de Groot S R, Dolgov A, Dolgov A D, Dolgov A D, Ellis John, Firmani C, Ghigna S, Groom D E (Particle Data Group), Hansen S H, Hogan C J, Hogan C J, Kawasaki M, Kawasaki M, Landau L D, Luis G Cabral-Rosetti, Maartens R, Matos T, Matos T, Mohapatra R N, Moore B, Padmanabhan T, Pal P B, Pal P B, Peacock C, Roberto A Sussman, Roszkowski L, Roszkowski L, Salucci P, Tonatiuh Matos, Trimble V   +39 more
core   +2 more sources