Results 81 to 90 of about 1,978,218 (342)

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons, Nuria Guillen, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller‐Gauxax, Magda Castellví, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell, Josep M. Augè Fradera, Gerard Piñol, Iolanda Riba, Anna Carnes‐Vendrell, Marta Cullell, Maria Teresa Osuna, Lorena Bajo, Teresa Romero, Eva Bonjoch, Joan Bello, Susana Fernández, Marta Balagué, Isabel Gómez‐Ruiz, Anuncia Boltes, Claustre Pont, Raquel Cuevas, Sara Carrillo, Laura Iglesias, Teresa Maria Casadevall Codina, Lorena Grau Guinea, Fernando Jose Espada, Raquel Sánchez‐Valle, Mircea Balasa, Albert Lladó   +33 more
wiley   +1 more source

« Changement » et « innovation » : Essai d’intégration théorique au cœur d’un programme de recherche mené en anthropologie culturaliste

Éducation et Socialisation, 2020
This article attempts to question the possible theoretical integration of the concepts of "innovation" and "change" within the framework of a research program conducted in cultural anthropology and mainly inspired by the analytical philosophy of ...
Jérôme Amathieu, Sébastien Chaliès
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

PTSL Wujud Pelaksanaan Kewajiban Pemerintah untuk Menjamin Kepastian dan Perlindungan Hukum Atas Kepemilikan Tanah

Jurnal Cakrawala Hukum, 2019
Land registration is a government program in order to obtain legal certainty and legal protection for holders of land rights. While the process of making land certificates is considered slow so that it becomes the government’s attention, to overcome this
Tri Susilaningsih
doaj   +1 more source

Towards an integrated discovery system [PDF]

, 1987
Previous research on machine discovery has focused on limited parts of the empirical discovery task. In this paper we describe IDS, an integrated system that addresses both qualitative and quantitative discovery.
Langley, Pat, Nordhausen, Bernd
core   +1 more source

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

An Evaluation Use Framework and Empirical Assessment

Journal of MultiDisciplinary Evaluation, 2009
Background: Research on evaluation use focuses on putting evaluation recommendations into practice. Prior theoretical research proposes varied frameworks for understanding the use (or lack) of program evaluation results.
Laura R Peck, Lindsey M Gorzalski
doaj   +1 more source

Externalism and Empirical Research Programs in Semantics

Prolegomena, 2014
The paper considers (causal) semantic externalism as a potential basis for an empirical research program in semantics and claims that externalism has not and cannot deliver in this respect. Externalism claims that content, at least for certain classes of expressions or concepts, is, at least in part, determined or individuated by factors external to ...
openaire   +4 more sources

What do we know about the effects of the Alaska Permanent Fund Dividend? [PDF]

, 2019
The Alaska Permanent Fund Dividend (PFD) has been distributed to Alaska residents for 37 years, providing each resident an equal share of a yearly government appropriation based on the earnings of the Alaska Permanent Fund.
Guettabi, Mouhcine
core