Results 121 to 130 of about 27,179 (258)

Styles of ejecta emplacement under atmospheric conditions

, 1991
Laboratory experiments provide essential first-order constraints on processes affecting ballistic ejecta and styles of ejecta emplacement under different atmospheric environments at planetary scales.
Schultz, P. H.
core  

Integrating multi-source remote sensing, field work, and petrography for automatic lithological mapping and mineralization potential in the Gabal El-Faraid, Egypt. [PDF]

Sci Rep
Osman H, Azer MK, Zaky KS, Ali S, Farahat ES, Abo Khashaba SM.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Asynchronous transfer of magmas and mineralizing fluids in a plutonic-subvolcanic-volcanic plumbing system. [PDF]

Sci Rep
Paoli G, Dini A, Vezzoni S, Ovtcharova M, Rocchi S.   +4 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Martian mid-latitude subsurface ice is the remnant of a past ice sheet. [PDF]

Commun Earth Environ
Vos E, Forget F, Lange L, Naar J, Clement JB, Millour E.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Rheological evolution of a trachybasalt from Mt. Etna under slow cooling. [PDF]

Sci Data
Di Fiore F, Vona A.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Granitic intrusions enhance strain localization and rapid mantle exhumation along an oceanic detachment fault. [PDF]

Sci Adv
Poulaki EM, Bickert M, Vannucchi P, Shuck BD, Akizawa N, Pandey A, Morishita T, Sanfilippo A, Cunningham EH, Barnes JD, Garber JM, Nistor C, Bernard R, Tribuzio R, Loocke M, Abe N, Di Stefano A, Filina IY, Fu Q, Gontharet SBL, Kearns LE, Koorapati RK, Lei C, Loreto MF, Magri L, Menapace W, Pavlovics VL, Pezard PA, Rodriguez-Pilco MA, Zhao X, Pérez-Gussinyé M, Garrido CJ, Ranero CR, Estes ER, Malinverno A, Zitellini N.   +35 more
europepmc   +1 more source